TY  - JOUR
AU  - Griffiths, P. J.
AU  - Isackson, H.
AU  - Pelc, R.
AU  - Redwood, C. S.
AU  - Funari, S. S.
AU  - Watkins, H.
AU  - Ashley, C. C.
AU  - DESY
TI  - Synchronous In Situ ATPase Activity, Mechanics, and Ca2<sup>+</sup> Sensitivity of Human and Porcine Myocardium
JO  - Biophysical journal
VL  - 97
SN  - 0006-3495
CY  - New York, NY
PB  - Rockefeller Univ. Press
M1  - PHPPUBDB-11771
SP  - 2503-2512
PY  - 2009
AB  - Flash-frozen myocardium samples provide a valuable means of correlating clinical cardiomyopathies with abnormalities in sarcomeric contractile and biochemical parameters. We examined flash-frozen left-ventricle human cardiomyocyte bundles from healthy donors to determine control parameters for isometric tension (P(o)) development and Ca(2+) sensitivity, while simultaneously measuring actomyosin ATPase activity in situ by a fluorimetric technique. P(o) was 17 kN m(-2) and pCa(50
KW  - Actomyosin: chemistry
KW  - Adenosine Triphosphatases: chemistry
KW  - Adenosine Triphosphate: chemistry
KW  - Animals
KW  - Biophysics: methods
KW  - Calcium: chemistry
KW  - Calcium: metabolism
KW  - Fluorometry: methods
KW  - Glycerol: chemistry
KW  - Humans
KW  - Hydrogen-Ion Concentration
KW  - Microscopy, Atomic Force: methods
KW  - Myocardial Contraction
KW  - Myocardium: metabolism
KW  - Myocardium: pathology
KW  - Myosins: chemistry
KW  - Swine
KW  - Adenosine Triphosphate (NLM Chemicals)
KW  - Glycerol (NLM Chemicals)
KW  - Calcium (NLM Chemicals)
KW  - Actomyosin (NLM Chemicals)
KW  - Adenosine Triphosphatases (NLM Chemicals)
KW  - Myosins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:19883593
C2  - pmc:PMC2770627
UR  - <Go to ISI:>//WOS:000271454000016
DO  - DOI:10.1016/j.bpj.2009.07.058
UR  - https://bib-pubdb1.desy.de/record/93894
ER  -