%0 Journal Article
%A Griffiths, P. J.
%A Isackson, H.
%A Pelc, R.
%A Redwood, C. S.
%A Funari, S. S.
%A Watkins, H.
%A Ashley, C. C.
%A DESY
%T Synchronous In Situ ATPase Activity, Mechanics, and Ca2<sup>+</sup> Sensitivity of Human and Porcine Myocardium
%J Biophysical journal
%V 97
%@ 0006-3495
%C New York, NY
%I Rockefeller Univ. Press
%M PHPPUBDB-11771
%P 2503-2512
%D 2009
%X Flash-frozen myocardium samples provide a valuable means of correlating clinical cardiomyopathies with abnormalities in sarcomeric contractile and biochemical parameters. We examined flash-frozen left-ventricle human cardiomyocyte bundles from healthy donors to determine control parameters for isometric tension (P(o)) development and Ca(2+) sensitivity, while simultaneously measuring actomyosin ATPase activity in situ by a fluorimetric technique. P(o) was 17 kN m(-2) and pCa(50
%K Actomyosin: chemistry
%K Adenosine Triphosphatases: chemistry
%K Adenosine Triphosphate: chemistry
%K Animals
%K Biophysics: methods
%K Calcium: chemistry
%K Calcium: metabolism
%K Fluorometry: methods
%K Glycerol: chemistry
%K Humans
%K Hydrogen-Ion Concentration
%K Microscopy, Atomic Force: methods
%K Myocardial Contraction
%K Myocardium: metabolism
%K Myocardium: pathology
%K Myosins: chemistry
%K Swine
%K Adenosine Triphosphate (NLM Chemicals)
%K Glycerol (NLM Chemicals)
%K Calcium (NLM Chemicals)
%K Actomyosin (NLM Chemicals)
%K Adenosine Triphosphatases (NLM Chemicals)
%K Myosins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:19883593
%2 pmc:PMC2770627
%U <Go to ISI:>//WOS:000271454000016
%R 10.1016/j.bpj.2009.07.058
%U https://bib-pubdb1.desy.de/record/93894