TY  - JOUR
AU  - Barcelo, F.
AU  - Perona, J. S.
AU  - Prades, J.
AU  - Funari, S. S.
AU  - Gomez-Gracia, E.
AU  - Conde, M.
AU  - Estruch, R.
AU  - Ruiz-Gutierrez, V.
AU  - DESY
TI  - Mediterranean-Style Diet Effect on the Structural Properties of the Erythrocyte Cell Membrane of Hypertensive Patients
JO  - Hypertension
VL  - 54
SN  - 0362-4323 
CY  - Baltimore, Md.
PB  - Williams & Wilkins
M1  - PHPPUBDB-10519
SP  - 1143-1150
PY  - 2009
AB  - A currently ongoing randomized trial has revealed that the Mediterranean diet, rich in virgin olive oil or nuts, reduces systolic blood pressure in high-risk cardiovascular patients. Here, we present a structural substudy to assess the effect of a Mediterranean-style diet supplemented with nuts or virgin olive oil on erythrocyte membrane properties in 36 hypertensive participants after 1 year of intervention. Erythrocyte membrane lipid composition, structural properties of reconstituted erythrocyte membranes, and serum concentrations of inflammatory markers are reported. After the intervention, the membrane cholesterol content decreased, whereas that of phospholipids increased in all of the dietary groups; the diminishing cholesterol:phospholipid ratio could be associated with an increase in the membrane fluidity. Moreover, reconstituted membranes from the nuts and virgin olive oil groups showed a higher propensity to form a nonlamellar inverted hexagonal phase structure that was related to an increase in phosphatidylethanolamine lipid class. These data suggest that the Mediterranean-style diet affects the lipid metabolism that is altered in hypertensive patients, influencing the structural membrane properties. The erythrocyte membrane modulation described provides insight in the structural bases underlying the beneficial effect of a Mediterranean-style diet in hypertensive subjects.
KW  - Aged
KW  - Analysis of Variance
KW  - Blood Pressure Determination
KW  - C-Reactive Protein: metabolism
KW  - Cardiovascular Diseases: prevention & control
KW  - Cholesterol: blood
KW  - Diet, Mediterranean
KW  - E-Selectin: blood
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Erythrocyte Membrane: metabolism
KW  - Erythrocyte Membrane: pathology
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Hypertension: diagnosis
KW  - Hypertension: diet therapy
KW  - Inflammation Mediators: analysis
KW  - Lipids: blood
KW  - Male
KW  - Middle Aged
KW  - Nuts
KW  - P-Selectin: blood
KW  - Plant Oils
KW  - Probability
KW  - Severity of Illness Index
KW  - Time Factors
KW  - Treatment Outcome
KW  - E-Selectin (NLM Chemicals)
KW  - Inflammation Mediators (NLM Chemicals)
KW  - Lipids (NLM Chemicals)
KW  - P-Selectin (NLM Chemicals)
KW  - Plant Oils (NLM Chemicals)
KW  - Cholesterol (NLM Chemicals)
KW  - olive oil (NLM Chemicals)
KW  - C-Reactive Protein (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:19805640
UR  - <Go to ISI:>//WOS:000270992100035
DO  - DOI:10.1161/HYPERTENSIONAHA.109.137471
UR  - https://bib-pubdb1.desy.de/record/87393
ER  -