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@ARTICLE{Mller:81612,
      author       = {Müller, S. and Lange, S. and Gautel, M. and Wilmanns, M.
                      and DESY},
      title        = {{R}igid conformation of an immunoglobulin domain tandem
                      repeat in the {A}-band of the elastic muscle protein titin.},
      journal      = {Journal of molecular biology},
      volume       = {371},
      issn         = {0022-2836},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {PHPPUBDB-6302},
      pages        = {480},
      year         = {2007},
      abstract     = {Most of the structure of the giant muscle protein titin is
                      formed by small modular domains. Many of them are predicted
                      to be arranged in repeats with short linkers that may be key
                      determinants of the peculiar elastic properties of titin.
                      Here, we present the molecular structure of a tandem
                      arrangement of two immunoglobulin-like domains, A168 and
                      A169, located within the A-band segment of titin. The two
                      domains are connected by a 17 residue long beta-strand and
                      form a common interface. Based on these data, we establish
                      general principles to estimate the amount of conformational
                      flexibility of tandem domain motifs in titin. An unusual
                      bulge within the second domain, A169, is directly involved
                      into binding to a sarcomeric ligand, MURF-1, thus suggesting
                      a dual role of this tandem for both the mechanical
                      properties of titin and for sarcomeric signaling.},
      keywords     = {Alanine: chemistry / Amino Acid Sequence / Conserved
                      Sequence / Crystallography, X-Ray / Elasticity / Humans /
                      Immunoglobulins: chemistry / Ligands / Models, Molecular /
                      Molecular Sequence Data / Muscle Proteins: chemistry /
                      Protein Binding / Protein Kinases: chemistry / Protein
                      Structure, Secondary / Protein Structure, Tertiary /
                      Sequence Alignment / Tandem Repeat Sequences /
                      Immunoglobulins (NLM Chemicals) / Ligands (NLM Chemicals) /
                      Muscle Proteins (NLM Chemicals) / connectin (NLM Chemicals)
                      / Alanine (NLM Chemicals) / Protein Kinases (NLM Chemicals)},
      cin          = {EMBL},
      ddc          = {570},
      cid          = {$I:(DE-H253)EMBL_-2012_-20130307$},
      pnm          = {FS Beamline without reference (POF1-550)},
      pid          = {G:(DE-H253)POF1-No-Ref-20130405},
      experiment   = {EXP:(DE-H253)Unknown-BL-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17574571},
      UT           = {WOS:000248509100017},
      doi          = {10.1016/j.jmb.2007.05.055},
      url          = {https://bib-pubdb1.desy.de/record/81612},
}