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@ARTICLE{Stellato:80585,
author = {Stellato, F. and Menestrina, G. and Serra, M. D. and
Potrich, C. and Tomazzolli, R. and Meyer Klaucke, W. and
Morante, S. and DESY},
title = {{M}etal binding in amyloid beta-peptides shows intra- and
inter-peptide coordination modes.},
journal = {European biophysics journal},
volume = {35},
issn = {0175-7571},
address = {Berlin},
publisher = {Springer},
reportid = {PHPPUBDB-2651},
pages = {12},
year = {2006},
abstract = {X-ray absorption spectroscopy data show different metal
binding site structures in beta-amyloid peptides according
to whether they are complexed with Cu(2+) or Zn(2+) ions.
While the geometry around copper is stably consistent with
an intra-peptide binding with three metal-coordinated
Histidine residues, the zinc coordination mode depends on
specific solution conditions. In particular, different
sample preparations are seen to lead to different geometries
around the absorber that are compatible with either an
intra- or an inter-peptide coordination mode. This result
reinforces the hypothesis that assigns different
physiological roles to the two metals, with zinc favoring
peptide aggregation and, as a consequence, plaque
formation.},
keywords = {Amyloid beta-Peptides: chemistry / Cations, Divalent /
Copper: chemistry / Fourier Analysis / Histidine: chemistry
/ Imidazoles: chemistry / Models, Molecular / Protein
Binding / Protein Conformation / Spectrum Analysis: methods
/ X-Rays / Zinc: chemistry / Amyloid beta-Peptides (NLM
Chemicals) / Cations, Divalent (NLM Chemicals) / Imidazoles
(NLM Chemicals) / Histidine (NLM Chemicals) / Copper (NLM
Chemicals) / Zinc (NLM Chemicals) / imidazole (NLM
Chemicals)},
cin = {EMBL},
ddc = {570},
cid = {$I:(DE-H253)EMBL_-2012_-20130307$},
pnm = {Facility (machine) DORIS/PETRA (POF1-DORIS-PETRA-20130405)},
pid = {G:(DE-H253)POF1-DORIS-PETRA-20130405},
experiment = {EXP:(DE-H253)DORISIII(machine)-20150101},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:16404590},
UT = {WOS:000235900400005},
doi = {10.1007/s00249-005-0041-7},
url = {https://bib-pubdb1.desy.de/record/80585},
}