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000080585 1001_ $$aStellato, F.
000080585 1101_ $$aDESY$$bEuropean Molecular Biology Laboratory
000080585 245__ $$aMetal binding in amyloid beta-peptides shows intra- and inter-peptide coordination modes.
000080585 260__ $$aBerlin$$bSpringer$$c2006
000080585 300__ $$a12
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000080585 440_0 $$0PERI:(DE-600)1398349-0$$aEur. Biophys. J.$$v11$$x0175-7571$$y1
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000080585 520__ $$aX-ray absorption spectroscopy data show different metal binding site structures in beta-amyloid peptides according to whether they are complexed with Cu(2+) or Zn(2+) ions. While the geometry around copper is stably consistent with an intra-peptide binding with three metal-coordinated Histidine residues, the zinc coordination mode depends on specific solution conditions. In particular, different sample preparations are seen to lead to different geometries around the absorber that are compatible with either an intra- or an inter-peptide coordination mode. This result reinforces the hypothesis that assigns different physiological roles to the two metals, with zinc favoring peptide aggregation and, as a consequence, plaque formation.
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000080585 650_7 $$00$$2NLM Chemicals$$aAmyloid beta-Peptides
000080585 650_7 $$00$$2NLM Chemicals$$aCations, Divalent
000080585 650_7 $$00$$2NLM Chemicals$$aImidazoles
000080585 650_7 $$071-00-1$$2NLM Chemicals$$aHistidine
000080585 650_7 $$07440-50-8$$2NLM Chemicals$$aCopper
000080585 650_7 $$07440-66-6$$2NLM Chemicals$$aZinc
000080585 650_7 $$07GBN705NH1$$2NLM Chemicals$$aimidazole
000080585 650_2 $$2MeSH$$aAmyloid beta-Peptides: chemistry
000080585 650_2 $$2MeSH$$aCations, Divalent
000080585 650_2 $$2MeSH$$aCopper: chemistry
000080585 650_2 $$2MeSH$$aFourier Analysis
000080585 650_2 $$2MeSH$$aHistidine: chemistry
000080585 650_2 $$2MeSH$$aImidazoles: chemistry
000080585 650_2 $$2MeSH$$aModels, Molecular
000080585 650_2 $$2MeSH$$aProtein Binding
000080585 650_2 $$2MeSH$$aProtein Conformation
000080585 650_2 $$2MeSH$$aSpectrum Analysis: methods
000080585 650_2 $$2MeSH$$aX-Rays
000080585 650_2 $$2MeSH$$aZinc: chemistry
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000080585 7001_ $$aMenestrina, G.
000080585 7001_ $$aSerra, M. D.
000080585 7001_ $$aPotrich, C.
000080585 7001_ $$aTomazzolli, R.
000080585 7001_ $$aMeyer Klaucke, W.
000080585 7001_ $$aMorante, S.
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