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@ARTICLE{Krabbes:646508,
      author       = {Krabbes, Maria and Kampik, Vincent and Büttner, Mathilde
                      and Kaysser, Leonard and Schneck, Emanuel and Shen, Chen and
                      Woelk, Christian},
      title        = {{I}ntrinsic {S}tructure of {L}ipoplexes {E}mbedded in
                      {P}olyelectrolyte {M}ultilayers},
      journal      = {Langmuir},
      volume       = {42},
      number       = {7},
      issn         = {0743-7463},
      address      = {Washington, DC},
      publisher    = {ACS Publ.},
      reportid     = {PUBDB-2026-00885},
      pages        = {5485 - 5496},
      year         = {2026},
      abstract     = {The functionalization of surfaces with therapeutically
                      applicable nucleic acid carriers provides promising
                      strategies in biomedical research to develop therapies that
                      focus on local nucleic acid delivery. One such approach is
                      the embedding of lipoplexes (LPXs) in polysaccharide-based
                      polyelectrolyte multilayers (PEMs). PEMs based on hyaluronic
                      acid and chitosan lead to efficient embedding of customized
                      LPX connected with good biological activity. However,
                      although quantitative evaluation demonstrates LPX embedding,
                      information about detailed characteristics of embedded LPXs
                      has been missing. In this study, we used synchrotron-based
                      grazing-incidence small-angle X-ray scattering to
                      investigate the effects of the change in the chemical
                      environment caused by the embedding into PEMs on the LPX’s
                      internal mesoscopic structure. While the lamellar character
                      of the LPXs was preserved, the repeat distance was affected
                      by embedding into polysaccharide-based coatings.},
      cin          = {FS-PETRA-D / DOOR ; HAS-User},
      ddc          = {540},
      cid          = {I:(DE-H253)FS-PETRA-D-20210408 /
                      I:(DE-H253)HAS-User-20120731},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)
                      / FS-Proposal: R-20240669 (R-20240669) / DFG project
                      G:(GEPRIS)396823779 - Entwicklung von Lipoplex-beladenen
                      Modelloberflächen für die in situ Transfektion im Bereich
                      der Knochenregeneration (396823779)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3 /
                      G:(DE-H253)R-20240669 / G:(GEPRIS)396823779},
      experiment   = {EXP:(DE-H253)P-P08-20150101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1021/acs.langmuir.5c05543},
      url          = {https://bib-pubdb1.desy.de/record/646508},
}