TY  - JOUR
AU  - Tielemans, Birger
AU  - Llambrich, Sergi
AU  - Seldeslachts, Laura
AU  - Cremer, Jonathan
AU  - Tsui, Hung Chang
AU  - Jonckheere, Anne-Charlotte
AU  - Marain, Nora Fopke
AU  - Riedel, Mirko
AU  - Wouters, Jens
AU  - Herzen, Julia
AU  - Leszczyński, Bartosz
AU  - Verbeken, Erik
AU  - Vanoirbeek, Jeroen
AU  - Vande Velde, Greetje
TI  - Cardiopulmonary and Immune Alterations in the Ts65Dn Mouse Model of Down Syndrome and Modulation by Epigallocatechin-3-Gallate-Enriched Green Tea Extract
JO  - Pharmaceutics
VL  - 17
IS  - 11
SN  - 1999-4923
CY  - Basel
PB  - MDPI
M1  - PUBDB-2026-00473
SP  - 1366 
PY  - 2025
AB  - Background/Objectives: Cardiovascular and pulmonary diseases are leading comorbidities n individuals with Down syndrome (DS). Although clinically well described, preclinical models fully characterizing these cardiopulmonary alterations are lacking. Our objective is to characterize the cardiopulmonary and immunological phenotype in a commonly used DS mouse model, the Ts65Dn mice, and investigate the modulatory effects of green tea extract enriched in epigallocatechin-3-gallate (GTE-EGCG); Methods: Treatment started at embryonic day 9 and continued until postnatal day (PD) 180. Mice were longitudinally monitored using micro-computed tomography, and structural, functional, and immunological alterations were evaluated at PD210 to determine the persistent effects of GTE-EGCG administration; Results: Ts65Dn mice displayed normal structural lung development and presented with right ventricular hypertrophy and reduced B-cell lymphocytes, indicating that this model may find applications in immunological respiratory research specific to the context of DS. GTE-EGCG administration induced transient lung immaturity, persistent decreases in lung function, and airway hyperreactivity, while normalizing arterial and right ventricular morphology and partially restoring B-cell lymphocyte numbers; Conclusions: These findings underscore the dual nature of EGCG modulation, both beneficial and adverse, and highlight the importance of a multiorgan, holistic approach when evaluating therapeutic interventions in DS models.Keywords:Down syndrome; Ts65Dn mouse model; heart and lung development; modulation by green tea extract enriched in epigallocatechin-3-gallate; cardiovascular and immune alterations 
LB  - PUB:(DE-HGF)16
DO  - DOI:10.3390/pharmaceutics17111366
UR  - https://bib-pubdb1.desy.de/record/644930
ER  -