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@ARTICLE{Vaskan:644606,
      author       = {Vaskan, I. S. and Petoukhov, M. V. and Bovin, N. V. and
                      Ryzhov, I. M. and Dimitreva, V. A. and Shtykova, E. V. and
                      Oleinikov, V. A. and Zalygin, A. V.},
      title        = {{S}tructure of {S}upramers {F}ormed by {G}lycolipid
                      {A}nalogues: {SAXS} {S}tudy},
      journal      = {Bulletin of the Russian Academy of Sciences / Physics},
      volume       = {89},
      number       = {S2},
      issn         = {1062-8738},
      address      = {New York, NY},
      publisher    = {Allerton Press},
      reportid     = {PUBDB-2026-00439},
      pages        = {S347 - S352},
      year         = {2025},
      abstract     = {Synthetic glycolipids and similar amphiphils with peptide
                      and other head groups have been designed for
                      labeling/modification of living cells under mild
                      physiological conditions. Under-standing the mechanism of
                      their penetration through the cellular glycocalyx and
                      subsequent insertion into the plasma membrane opens up the
                      prospect of improving the recently found anti-tumor
                      properties of such constructs. In this work, we applied
                      small-angle X-ray scattering (SAXS) technique to
                      characterize structure of nanoparticles formed by
                      self-assembly of synthetic glycolipid A (type 2)-Ad-DE and
                      to estimate its dependence on the glycolipid concentration.
                      The studies were performed at a range of SAXS-applicable
                      concentrations. The obtained results indicate that
                      self-assembly process leads to formation of monodisperse
                      nanoparticles with micelle-like architecture, which is
                      maintained regardless of concentration, indicating absence
                      of the nanoparticle’s positive interaction with their
                      glycopart. We applied ab initio modeling that showed a good
                      agreement with experimental data, and found that the
                      ellipsoid monodisperse nanoparticles have a size of about 14
                      nm. Quasi-atomic modeling visualised that glycan ligands are
                      well accessed for biological recognition. This knowledge
                      will facilitate further study of the formation of the
                      supramolecular form(s) of A(type 2)-Ad-DE and other
                      glycolipids within the glycocalyx and its further fate in
                      new therapeutic strategies.},
      cin          = {EMBL-User},
      ddc          = {530},
      cid          = {I:(DE-H253)EMBL-User-20120814},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P12-20150101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1134/S1062873825714618},
      url          = {https://bib-pubdb1.desy.de/record/644606},
}