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@ARTICLE{Kortman:642190,
      author       = {Kortman, Hannah M. and Fang, Hao and Bastick, Kane A. C.
                      and Völkel, Charlotte and Oberthür, Dominik and Seeberger,
                      Peter H. and Perbandt, Markus and Molloy, John J.},
      title        = {{F}used 3{D} boron heterocycles via {E}n{T} catalysis:
                      synthesis, modification and validation as beta-lactamase
                      inhibitors},
      journal      = {Chemical science},
      volume       = {17},
      number       = {1},
      issn         = {2041-6520},
      address      = {Cambridge},
      publisher    = {RSC},
      reportid     = {PUBDB-2025-05386},
      pages        = {247 - 254},
      year         = {2026},
      note         = {cc-by},
      abstract     = {The installation of a boron unit into bioactive scaffolds
                      continues to unlock novel modes of molecular recognition in
                      drug discovery. As such, de novo strategies to access 3D
                      boron-containing frameworks, that modulate the intrinsic
                      reactivity at boron, are being intensively pursued. Herein,
                      we report a visible light-mediated energy transfer (EnT)
                      catalysis strategy that enables the [2 + 2] cycloaddition of
                      boron-containing heterocycles to construct 3D frameworks
                      with high structural complexity. Leveraging both inter- and
                      intramolecular cycloadditions, a suite of angularly fused
                      boron heterocycles was accessed, offering enhanced steric
                      shielding and modular handles for additional interactions. A
                      boron deletion strategy permits the synthesis of benzofuran
                      scaffolds, otherwise inaccessible via direct EnT. Crucially,
                      the resulting 3D architectures mimic structural motifs found
                      in the potent β-lactamase inhibitor Xeruborbactam. The
                      biological relevance of these frameworks was validated by
                      NMR titration, pKa analysis, and co-crystallisation with
                      serine β-lactamase CTX-M-14, revealing enantiospecific
                      binding and a well-defined hydrogen bonding network. These
                      results establish a versatile platform for the synthesis of
                      functionalised boron heterocycles with direct translational
                      potential in medicinal chemistry.},
      cin          = {$HH_FS_CFEL-1$ / FS-CFEL-1},
      ddc          = {540},
      cid          = {$I:(DE-H253)HH_FS_CFEL-1-20241217$ /
                      I:(DE-H253)FS-CFEL-1-20120731},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / DFG project G:(GEPRIS)431232613 -
                      SFB 1449: Dynamische Hydrogele an Biogrenzflächen
                      (431232613) / FS-Proposal: BAG-20230677 (BAG-20230677)},
      pid          = {G:(DE-HGF)POF4-633 / G:(GEPRIS)431232613 /
                      G:(DE-H253)BAG-20230677},
      experiment   = {EXP:(DE-H253)P-P11-20150101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1039/D5SC05518K},
      url          = {https://bib-pubdb1.desy.de/record/642190},
}