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@ARTICLE{Pazicky:641985,
      author       = {Pazicky, Samuel and Tjia, Seth and Farias, Guilherme and
                      Piwon, Nick and Philip, Nisha and Sobota, Radoslaw M. and
                      Waters, Andrew P. and Gilberger, Tim-Wolf and Bozdech,
                      Zbynek},
      title        = {{MAP}-{X} reveals distinct protein complex dynamics across
                      {P}lasmodium falciparum blood stages},
      journal      = {Nature microbiology},
      volume       = {10},
      number       = {12},
      issn         = {2058-5276},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {PUBDB-2025-05272},
      pages        = {3229 - 3244},
      year         = {2025},
      note         = {Waiting for fulltext},
      abstract     = {The malaria parasite Plasmodium falciparum undergoes a
                      complex intraerythrocytic developmental cycle (IDC) that
                      relies on a dynamic network of protein–protein
                      interactions. These are usually mapped ex vivo, limiting our
                      understanding of their dynamics and composition in natural
                      environments. Here we introduce the meltome-assisted
                      profiling of protein complexes (MAP-X) that maps the
                      complexome through thermal proteome profiling in intact
                      cells. We applied MAP-X across seven timepoints in the P.
                      falciparum IDC. MAP-X predicted more than 20,000
                      interactions, resolving conserved protein complexes,
                      reproducing previously identified interactions and finding
                      previously unreported associations. We found that malaria
                      protein complexes undergo distinct dynamic alterations, and
                      we predicted their moonlighting subunits that dissociate
                      from their native complex to assume different biological
                      functions. Altogether, our findings provide a resource for
                      uncovering Plasmodium biology and show that MAP-X can
                      characterize protein complexes in intact cells to reveal
                      cellular physiology at a proteome-wide level.},
      cin          = {CSSB-BNITM-TG},
      ddc          = {570},
      cid          = {I:(DE-H253)CSSB-BNITM-TG-20210520},
      pnm          = {899 - ohne Topic (POF4-899) / GRK 2771 - GRK 2771: Mensch
                      und Mikrobe: Reorganisation von Zellkompartimenten und
                      Molekülkomplexen während der Infektion (453548970)},
      pid          = {G:(DE-HGF)POF4-899 / G:(GEPRIS)453548970},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1038/s41564-025-02173-7},
      url          = {https://bib-pubdb1.desy.de/record/641985},
}