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@ARTICLE{Sheernaly:641966,
      author       = {Sheernaly, Nandan and Steinbrueck, Axel and Krahn, Nicolas
                      and Rumancev, Christoph and Peeters, Frank and Jusufagic,
                      Lejla and Ochs, Jasmine and Garrevoet, Jan and Falkenberg,
                      Gerald and Rosenhahn, Axel and Metzler-Nolte, Nils},
      title        = {{I}nvestigating {M}etal and {F}luorophore {C}ontrolled
                      {I}ntracellular {L}ocalization in {N}oble {M}etal
                      {T}hiosemicarbazone {C}omplexes},
      journal      = {Chemistry - a European journal},
      volume       = {31},
      number       = {69},
      issn         = {0947-6539},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {PUBDB-2025-05253},
      pages        = {e02613},
      year         = {2025},
      note         = {cc-byonline first},
      abstract     = {Transition metal complexes have been widely utilized as
                      cellular imaging tools. To impart organelle specificity,
                      ligand architecture is usually modified to modulate
                      properties like overall charge and lipophilicity. In many
                      such designs, the metal identity and its intrinsic
                      properties are often ignored. To address this gap, in this
                      study, we explored the effects of changing the metal center
                      on the localization patterns of isostructural complexes. To
                      this end, we employed the thiosemicarbazone Dp44mT to
                      synthesize coumarin-conjugated complexes of Au(III), Pt(II),
                      and Pd(II). Although the metal centers in these compounds
                      share a formal d8 configuration, they differ in properties
                      such as ionic radius, charge density, and ligand exchange
                      rates, which can affect their subcellular localization
                      patterns. In addition, we synthesized a second set of
                      analogous complexes using BODIPY as the conjugating
                      fluorophore to assess the influence of using a different dye
                      on the cellular distribution. Confocal imaging revealed that
                      the complexes exhibited distinct intracellular
                      distributions. For instance, while the coumarin-conjugated
                      Pt(II) complex localized specifically in lysosomes, the
                      corresponding lipophilic Pd(II) complex lacked this
                      specificity and instead followed a diffusely cytosolic
                      distribution. Similarly, the more lipophilic BODIPY
                      conjugated complexes were non-specific in their cellular
                      distribution as well. Overall, the findings of this study
                      highlight the interplay of metal identity and lipophilicity
                      in determining the localization patterns of Dp44mT-based
                      metal complexes, offering fresh insights into the design of
                      new metal-based imaging tools.},
      cin          = {DOOR ; HAS-User / FS-PETRA-S},
      ddc          = {660},
      cid          = {I:(DE-H253)HAS-User-20120731 /
                      I:(DE-H253)FS-PETRA-S-20210408},
      pnm          = {631 - Matter – Dynamics, Mechanisms and Control
                      (POF4-631) / 6G3 - PETRA III (DESY) (POF4-6G3) / DFG project
                      G:(GEPRIS)518777768 - Entwicklung von Sonden für das
                      selektive Anfärben intrazellulärer Organelle in der
                      Röntgenfluoreszenzspektroskopie von menschlichen Zell- und
                      Gewebeproben (518777768) / DFG project G:(GEPRIS)525502632 -
                      Ortsaufgelöste röntgenfluoreszenzanalytische Untersuchung
                      der intrazellulären Verteilung von Platin und Gold
                      basierten Zytostatika und Vergleich mit rutheniumbasierten
                      Wirkstoffen. (525502632) / GRK 2341 - GRK 2341: Mikrobielle
                      Substratumsetzung (321933041) / FS-Proposal: II-20230017
                      (II-20230017)},
      pid          = {G:(DE-HGF)POF4-631 / G:(DE-HGF)POF4-6G3 /
                      G:(GEPRIS)518777768 / G:(GEPRIS)525502632 /
                      G:(GEPRIS)321933041 / G:(DE-H253)II-20230017},
      experiment   = {EXP:(DE-H253)P-P06-20150101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1002/chem.202502613},
      url          = {https://bib-pubdb1.desy.de/record/641966},
}