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@ARTICLE{Zaouali:641241,
      author       = {Zaouali, Ameni and Gloaguen, David and Le Bourhis, Eric and
                      Dubos, Pierre-Antoine and Moya, Marie-José and
                      Schwartzkopf, Matthias and Snow, Tim and Schneider, Konrad
                      and Chang, Baobao and Jordana, Fabienne and Tessier, Solène
                      and Tournier, Pierre and Paré, Arnaud and Weiss, Pierre and
                      Geoffroy, Valérie and Girault, Baptiste},
      title        = {{R}estoration of hydroxyapatite particle thickness and
                      crystalline orientation does not lead to recovery of
                      tissue-scale mechanical properties in regenerating rat
                      calvarial bone defects},
      journal      = {Journal of the mechanical behavior of biomedical materials},
      volume       = {168},
      issn         = {1751-6161},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {PUBDB-2025-04972},
      pages        = {106998},
      year         = {2025},
      note         = {Waiting for fulltext},
      abstract     = {Various cellular activities regulate bone healing, causing
                      structural changes and evolving mechanical characteristics
                      during the regeneration process. This pilot study aimed to
                      correlate the time- and space-resolved mechanical behavior
                      of regenerating and related biological processes. While the
                      mechanical properties of bone are known to be based on a
                      nanostructure organization, this study intends to highlight
                      the evolution of the strain distribution induced by the
                      reconstruction process, which is mainly driven by the
                      mineral part (i.e., hydroxyapatite) of the bone
                      architecture. Multiscale mechanical (tensile and
                      nanoindentation tests) and biological (X-ray microtomography
                      measurements and histological observations) characterization
                      methods were applied to 3 mm rat cranial defects, one of the
                      most reproducible animal models used to assess bone
                      regeneration, filled with bone grafts, the gold standard for
                      bone repair. The size and crystallographic orientation of
                      the hydroxyapatite particles as well as their lattice
                      (elastic) strain distribution under tensile loading were
                      investigated through in situ synchrotron wide-angle and
                      small-angle X-ray scattering measurements at various healing
                      stages. Analyses were completed to quantify the elastic
                      properties at the tissue-scale via nanoindentation
                      measurements. The resulting mappings of lattice strain, mean
                      particle thickness and crystallographic orientations
                      revealed how tissue evolves during bone repair. At the early
                      stages of the regeneration process, the microstructural
                      changes consisted of a restored hydroxyapatite platelet
                      shape and crystallographic orientation. At later stages, the
                      hydroxyapatite crystallographic orientation reached that of
                      native bone, and the mechanical function of the tissue in
                      the defect zone was restored at the mineral particle scale.
                      Nevertheless, even for the longest regeneration duration (20
                      weeks), mechanical properties at the tissue-scale remained
                      ineffective, highlighting the importance of multiscale
                      investigations to address this type of issue.},
      cin          = {DOOR ; HAS-User / FS-PETRA-D},
      ddc          = {570},
      cid          = {I:(DE-H253)HAS-User-20120731 /
                      I:(DE-H253)FS-PETRA-D-20210408},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)
                      / FS-Proposal: I-20170353 EC (I-20170353-EC) / FS-Proposal:
                      I-20180931 EC (I-20180931-EC) / CALIPSOplus - Convenient
                      Access to Light Sources Open to Innovation, Science and to
                      the World (730872)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3 /
                      G:(DE-H253)I-20170353-EC / G:(DE-H253)I-20180931-EC /
                      G:(EU-Grant)730872},
      experiment   = {EXP:(DE-H253)P-P03-20150101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.jmbbm.2025.106998},
      url          = {https://bib-pubdb1.desy.de/record/641241},
}