% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Mewes:640813,
      author       = {Mewes, Catharina and Lerch, Michael and Petasecca, Marco
                      and Klingenberg, Johannes and Abreu Faria, Guilherme and
                      Lienert, Ulrich and Schueltke, Elisabeth and Paino, Jason
                      and Cayley, James and Wegner, Marie and Fiedler, Stefan and
                      Gargioni, Elisabetta},
      title        = {{A} procedure for accurate dose measurement in radiotherapy
                      research at millimetre-sized synchrotron beams},
      journal      = {Physics in medicine and biology},
      volume       = {70},
      number       = {22},
      issn         = {0031-9155},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {PUBDB-2025-04916},
      pages        = {225015},
      year         = {2025},
      abstract     = {Objective. Synchrotron-based spatially fractionated
                      radiotherapy and ultra-high dose rate (UHDR) radiotherapy
                      have been shown to better spare healthy tissue function in
                      comparison to conventional radiotherapy, while controlling
                      the tumour with the same efficacy. In recent years, an
                      increasing amount of research has been carried out in these
                      fields with promising results. However, further experiments
                      remain essential, since the underlying mechanisms of healthy
                      tissue preservation are not yet fully understood. The
                      characterisation of synchrotron beamlines at the Deutsches
                      Elektronen-Synchrotron in Hamburg represents an opportunity
                      to increase the number of sites where pre-clinical studies
                      could be conducted in the future. However, the beams
                      available at this synchrotron are only a few millimetres in
                      size and measuring absorbed dose with established detectors
                      and dosimetry protocols represents a challenge. Approach. We
                      show a procedure to accurately determine the beam dose rate
                      under such conditions by first characterising a
                      monochromatic beamline. After validation, and with the
                      support of Monte Carlo simulations, the procedure is adapted
                      to investigate a white-beam beamline, at which photon flux
                      and mean energy can be varied with Cu absorbers. Main
                      results. With the developed procedure, it is possible to
                      measure absorbed dose at these beamlines with relative
                      uncertainties below $10\%.$ In particular, at the white-beam
                      beamline, the dose rate varies between about
                      20 Gy s$^{−1}$ and about 1800 Gy s$^{−1}$, thus
                      offering the opportunity to carry out much-needed systematic
                      studies. Moreover, pilot experiments with a mouse phantom
                      demonstrate that it is possible to treat small animals with
                      such small-sized beams by using dose-painting techniques,
                      with an agreement between prescribed and delivered dose
                      within ±15\%. Significance. This work represents a first
                      step towards the implementation of reproducible pre-clinical
                      studies at the PETRA III synchrotron, further contributing
                      to a transition of spatially-fractionated and UHDR
                      radiotherapy techniques into clinical practice.},
      cin          = {FS DOOR-User / FS-PET-D / Hereon},
      ddc          = {530},
      cid          = {$I:(DE-H253)FS_DOOR-User-20241023$ /
                      I:(DE-H253)FS-PET-D-20190712 / I:(DE-H253)Hereon-20210428},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)
                      / FS-Proposal: I-20211383 (I-20211383) / FS-Proposal:
                      I-20211485 (I-20211485) / FS-Proposal: I-20230467
                      (I-20230467)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3 /
                      G:(DE-H253)I-20211383 / G:(DE-H253)I-20211485 /
                      G:(DE-H253)I-20230467},
      experiment   = {EXP:(DE-H253)P-P61.1-20150101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1088/1361-6560/ae143a},
      url          = {https://bib-pubdb1.desy.de/record/640813},
}