%0 Journal Article
%A Mewes, Catharina
%A Lerch, Michael
%A Petasecca, Marco
%A Klingenberg, Johannes
%A Abreu Faria, Guilherme
%A Lienert, Ulrich
%A Schueltke, Elisabeth
%A Paino, Jason
%A Cayley, James
%A Wegner, Marie
%A Fiedler, Stefan
%A Gargioni, Elisabetta
%T A procedure for accurate dose measurement in radiotherapy research at millimetre-sized synchrotron beams
%J Physics in medicine and biology
%V 70
%N 22
%@ 0031-9155
%C Bristol
%I IOP Publ.
%M PUBDB-2025-04916
%P 225015 
%D 2025
%X Objective. Synchrotron-based spatially fractionated radiotherapy and ultra-high dose rate (UHDR) radiotherapy have been shown to better spare healthy tissue function in comparison to conventional radiotherapy, while controlling the tumour with the same efficacy. In recent years, an increasing amount of research has been carried out in these fields with promising results. However, further experiments remain essential, since the underlying mechanisms of healthy tissue preservation are not yet fully understood. The characterisation of synchrotron beamlines at the Deutsches Elektronen-Synchrotron in Hamburg represents an opportunity to increase the number of sites where pre-clinical studies could be conducted in the future. However, the beams available at this synchrotron are only a few millimetres in size and measuring absorbed dose with established detectors and dosimetry protocols represents a challenge. Approach. We show a procedure to accurately determine the beam dose rate under such conditions by first characterising a monochromatic beamline. After validation, and with the support of Monte Carlo simulations, the procedure is adapted to investigate a white-beam beamline, at which photon flux and mean energy can be varied with Cu absorbers. Main results. With the developed procedure, it is possible to measure absorbed dose at these beamlines with relative uncertainties below 10
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.1088/1361-6560/ae143a
%U https://bib-pubdb1.desy.de/record/640813