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@ARTICLE{Schwarzinger:640697,
      author       = {Schwarzinger, Jacqueline and Bello, Gianluca and Tropin,
                      Timur and Wölk, Christian and Blanchet, Clement and
                      Adelsberger, Sigrid and Hädrich, Gabriela and Rollinger,
                      Judith M. and Grienke, Ulrike and Harvey, Richard and
                      Dailey, Lea Ann},
      title        = {{P}ulmonary delivery of anti-infectives from natural
                      sources: {D}evelopment and characterization of liposomal
                      sanggenon formulations},
      journal      = {European journal of pharmaceutical sciences},
      volume       = {215},
      issn         = {0928-0987},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {PUBDB-2025-04837},
      pages        = {107361},
      year         = {2025},
      abstract     = {Sanggenon C (SGC) and sanggenon D (SGD) are stereoisomeric
                      natural products with promising anti-infective potential,
                      especially against pathogens involved in acute respiratory
                      infections. However, their bulky structures, poor aqueous
                      solubility, and low oral bioavailability present major
                      therapeutic challenges. Inhalation enables direct delivery
                      to the site of infection while minimizing systemic exposure.
                      Liposomal formulations DMPC:DMPG (2:1 w/w) of SGC and SGD,
                      prepared via ethanol injection, achieved high drug loadings
                      (> 3.5 mg/mL). Drug-lipid interactions were evaluated via
                      DSC, Langmuir trough studies, SAXS, and cryo-TEM, showing
                      incorporation of the compounds in the lipid bilayer. While
                      stereochemistry-dependent differences were evident in
                      vesicle size and thermotropic behavior, other biophysical
                      data indicated that these differences were largely mitigated
                      upon formulation. Liposomal formulations showed an excellent
                      stability during nebulization with a vibrating mesh
                      nebulizer (mass median aerodynamic diameters: 1.30–1.35
                      µm) and the high affinity of the compounds for the lipid
                      bilayer resulted in a sustained in vitro release profile
                      (8–9 $\%$ after 240 h). The retention of the drugs in the
                      liposomes also significantly reduced cytotoxicity at 24 h
                      compared to neat compounds. These findings highlight the
                      importance of stereochemistry in drug-membrane interaction,
                      yet their similar formulation performance suggests that both
                      compound formulations are promising candidates for pulmonary
                      anti-infective therapy.},
      cin          = {EMBL-User / EMBL},
      ddc          = {610},
      cid          = {I:(DE-H253)EMBL-User-20120814 / I:(DE-H253)EMBL-20120731},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P12-20150101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.ejps.2025.107361},
      url          = {https://bib-pubdb1.desy.de/record/640697},
}