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@ARTICLE{Faltinek:638557,
      author       = {Faltinek, Lukáš and Melicher, Filip and Kelemen, Viktor
                      and Mező, Erika and Borbás, Anikó and Wimmerová,
                      Michaela},
      title        = {{B}ispecific {T}hio‐{L}inked {D}isaccharides as
                      {I}nhibitors of {P}seudomonas {A}eruginosa {L}ectins
                      {L}ec{A} ({PA}‐{IL}) and {L}ec{B} ({PA}‐{IIL}):
                      {D}ual‐{T}argeting {S}trategy},
      journal      = {Chemistry - a European journal},
      volume       = {31},
      number       = {5},
      issn         = {0947-6539},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {PUBDB-2025-04111},
      pages        = {e202403546},
      year         = {2025},
      abstract     = {Pseudomonas aeruginosa is a prevalent opportunistic human
                      pathogen, particularly associated with cystic fibrosis.
                      Among its virulence factors are the LecA and LecB lectins.
                      Both lectins play an important role in the adhesion to the
                      host cells and display cytotoxic activity. In this study, we
                      successfully synthesized hardly hydrolysable carbohydrate
                      ligands targeting these pathogenic lectins, including two
                      bispecific glycans. The interactions between LecA/LecB
                      lectins and synthetic glycans were evaluated using
                      hemagglutination (yeast agglutination) inhibition assays,
                      comparing their efficacy with corresponding monosaccharides.
                      Additionally, the binding affinities of bispecific glycans
                      were assessed using isothermal titration calorimetry (ITC).
                      Structural insight into the lectin-ligand interaction was
                      obtained by determining the crystal structures of LecA/LecB
                      lectins in complex with one of the bispecific ligands using
                      X ray crystallography. This comprehensive investigation into
                      the inhibitory potential of synthetic glycosides against P.
                      aeruginosa lectins sheds light on their potential
                      application in antimicrobial therapy.},
      cin          = {EMBL-User},
      ddc          = {660},
      cid          = {I:(DE-H253)EMBL-User-20120814},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P13-20150101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1002/chem.202403546},
      url          = {https://bib-pubdb1.desy.de/record/638557},
}