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@ARTICLE{Marminon:638313,
      author       = {Marminon, Christelle and Werner, Christian and Gast,
                      Alexander and Herfindal, Lars and Charles, Johana and
                      Lindenblatt, Dirk and Aichele, Dagmar and Mularoni,
                      Angélique and Døskeland, Stein Ove and Jose, Joachim and
                      Niefind, Karsten and Le Borgne, Marc},
      title        = {{E}xploring the biological potential of the brominated
                      indenoindole {MC}11 and its interaction with protein kinase
                      {CK}2},
      journal      = {Biological chemistry},
      volume       = {406},
      number       = {3-4},
      issn         = {0018-4888},
      reportid     = {PUBDB-2025-04031},
      pages        = {125 - 138},
      year         = {2025},
      note         = {Deutsche Forschungsgemeinschaft (DFG) (grant no. INST
                      216/682-1 FUGG).},
      abstract     = {Protein kinase CK2 is a promising therapeutic target,
                      especially in oncology. Over the years, various inhibitors
                      have been developed, with polyhalogenated scaffolds emerging
                      as a particularly effective class. Halogens like bromine and
                      chlorine enhance inhibitor stability by forming additional
                      interactions within the ATP pocket. Among halogenated
                      scaffolds, benzotriazole and benzimidazole have led to
                      potent molecules such as 4,5,6,7-tetrabromo-1H-benzotriazole
                      (IC50 = 300 nM) and
                      4,5,6,7-tetrabromo-2-(dimethylamino)benzimidazole (IC50 =
                      140 nM). Modifications, including
                      4,5,6-tribromo-7-ethyl-1H-benzotriazole (IC50 = 160 nM),
                      further improved activity. Changing scaffolds while
                      retaining halogens has enabled design of new inhibitors.
                      Flavonols, dibenzofuranones, and the indeno[1,2-b]indole
                      scaffold are key examples. Halogenation of the reference
                      molecule
                      5-isopropyl-5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-dione
                      (4b, IC50 = 360 nM) significantly boosted potency. The
                      study focused on introducing four halogens, yielding to the
                      compound
                      1,2,3,4-tetrabromo-5-isopropyl-5,6,7,8-tetrahydroindeno[1,2-b]indole-9,10-dione
                      (MC11), with an IC50 of 16 nM. Co-crystallography revealed
                      how bromine atoms enhance binding, and MC11 demonstrated
                      strong in cellulo activity, particularly against leukemic
                      cell lines like IPC-Bcl2.},
      cin          = {EMBL-User},
      cid          = {I:(DE-H253)EMBL-User-20120814},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3) / DFG project
                      G:(GEPRIS)534044797 - Large Scale Data Facility 3 - Anteil
                      Forschungsgroßgerät (LSDF3-FuGG) (534044797)},
      pid          = {G:(DE-HGF)POF4-6G3 / G:(GEPRIS)534044797},
      experiment   = {EXP:(DE-H253)P-P13-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40116007},
      doi          = {10.1515/hsz-2024-0160},
      url          = {https://bib-pubdb1.desy.de/record/638313},
}