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@ARTICLE{Correa:638194,
      author       = {Correa, Yubexi and Nzekwe, Favour and Wodaje, Tigist and
                      Brinck, Jonas and Jansen, Martin and Blanchet, Clement and
                      Pedersen, Jan Skov and Del Giudice, Rita and Cárdenas,
                      Marité},
      title        = {{S}tructural, functional and biochemical characterisation
                      of apolipoprotein(a)-containing low-density lipoproteins},
      journal      = {Journal of colloid and interface science},
      volume       = {701},
      issn         = {0021-9797},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {PUBDB-2025-04012},
      pages        = {138760 -},
      year         = {2025},
      abstract     = {Atherosclerosis is the leading cause of cardiovascular
                      diseases and remains a global health challenge. Low-density
                      lipoproteins are crucial in atherogenesis, with plasma
                      levels as significant independent predictors of the
                      condition. Lipoprotein(a), Lp(a), is an LDL variant
                      considered a stand-alone atherosclerosis predictor. Although
                      structurally similar in composition to LDL, Lp(a) contains
                      an additional protein, apolipoprotein(a), covalently linked
                      to apolipoprotein-B100 via a disulfide bond. This
                      distinguishing protein is believed to confer Lp(a) its
                      distinctive properties, including marked heterogeneity.
                      While many studies have structurally characterised LDL
                      particles, Lp(a) remains understudied. In this study, we
                      isolated LDL particles from serum of normolipidemic, healthy
                      individuals with either low or high Lp(a) levels. Our study
                      provides biochemical, structural and functional
                      characterisation of low and high Lp(a)-total LDL fractions.
                      Fourier transform infrared spectroscopy (FTIR) revealed that
                      high Lp(a) LDL exhibited a reduced ability to remove lipids
                      from model membranes compared to low Lp(a) LDL. However,
                      this functional difference could not be sufficiently
                      associated with structural differences in total LDL
                      fractions, as determined by small-angle X-ray scattering
                      (SAXS), except for a significant difference in the
                      particles' core-to-shell scattering mass (SM) ratio. Western
                      blot analysis further revealed a higher abundance of Lp(a)
                      in a small-dense subfraction, LDL6, leading us to
                      hypothesise that structural differences might be more
                      evident in these subfractions than in total fractions.
                      Supporting this hypothesis, SAXS measurements on LDL6
                      subfractions from two subjects, with low and high Lp(a),
                      revealed an increased protein shell thickness in high Lp(a)
                      LDL6, a feature not directly observed in total fractions.
                      Our data thus suggests a key role of LDL6 in LDL
                      dysfunction.},
      cin          = {EMBL-User / EMBL},
      ddc          = {540},
      cid          = {I:(DE-H253)EMBL-User-20120814 / I:(DE-H253)EMBL-20120731},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P12-20150101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.jcis.2025.138760},
      url          = {https://bib-pubdb1.desy.de/record/638194},
}