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@ARTICLE{Burastero:635345,
      author       = {Burastero, Osvaldo and Jones, Nykola C and Defelipe, Lucas
                      A and Zavrtanik, Uroš and Hadži, San and Hoffmann, Søren
                      Vrønning and Garcia-Alai, Maria M},
      title        = {{C}hira{K}it: an online tool for the analysis of circular
                      dichroism spectroscopy data},
      journal      = {Nucleic acids symposium series},
      volume       = {53},
      number       = {W1},
      issn         = {0305-1048},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {PUBDB-2025-03100},
      pages        = {W158 - W168},
      year         = {2025},
      note         = {ISSN 1362-4962 not unique: **2 hits**.},
      abstract     = {Circular dichroism (CD) spectroscopy is an established
                      biophysical technique to study chiral molecules. CD allows
                      investigating conformational changes under varying
                      experimental conditions and has been used to understand
                      secondary structure, folding, and binding of proteins and
                      nucleic acids. Here, we present ChiraKit, a user-friendly,
                      online, and open-source tool to process raw CD data and
                      perform advanced analysis. ChiraKit features include the
                      calculation of protein secondary structure with the SELCON3
                      and SESCA algorithms, estimation of peptide helicity using
                      the helix-ensemble model, the fitting of thermal/chemical
                      unfolding or user-defined models, and the decomposition of
                      spectra through singular value decomposition or principal
                      component analysis. ChiraKit can be accessed at
                      https://spc.embl-hamburg.de/.},
      cin          = {CSSB-CF-SPC},
      ddc          = {540},
      cid          = {I:(DE-H253)CSSB-CF-SPC-20210520},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633)},
      pid          = {G:(DE-HGF)POF4-633},
      experiment   = {EXP:(DE-H253)SPC-20250101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40287821},
      doi          = {10.1093/nar/gkaf350},
      url          = {https://bib-pubdb1.desy.de/record/635345},
}