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@ARTICLE{RajaSomu:634681,
      author       = {Raja Somu, Dawn and Soini, Steven A. and Briggs, Ani and
                      Singh, Kritika and Greving, Imke and Porter, Marianne and
                      Passerotti, Michelle and Merk, Vivian},
      title        = {{A} {N}anoscale {V}iew of the {S}tructure and {D}eformation
                      {M}echanism of {M}ineralized {S}hark {V}ertebral
                      {C}artilage},
      journal      = {ACS nano},
      volume       = {19},
      number       = {14},
      issn         = {1936-0851},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {PUBDB-2025-02595},
      pages        = {14410 - 14421},
      year         = {2025},
      note         = {Waiting for fulltext},
      abstract     = {Swimming kinematics and macroscale mechanical testing have
                      shown that the vertebral column of sharks acts as a
                      biological spring, storing and releasing energy during
                      locomotion. Using synchrotron X-ray nanotomography and
                      deep-learning image segmentation, we studied the
                      ultrastructure and deformation mechanism of mineralized
                      shark vertebrae from Carcharhinus limbatus (Blacktip shark).
                      The vertebral centrum con regions: the corpus calcareum, a
                      hypermineralized double cone, and the intermediale, blocks
                      of mineralized cartilage interspersed by unmineralized
                      arches. At the micron scale, mineralized cartilage has
                      previously been described as a 3D network of interconnected
                      mineral plates that vary in thickness and spacing. The
                      corpus calcareum consists of stacked, interconnected, curved
                      mineralized planes permeated by a network of organic
                      occlusions. The mineral network in the intermedialia
                      resembles trabecular bone, including thicker struts in the
                      direction opposite to the predominant biological strain. We
                      characterized collagenous fiber elements winding around
                      lacunar spaces in the intermedialia, and we hypothesize the
                      swirling arrangement and elasticity of the fibers to be
                      distributing stress. With little permanent deformation
                      detected in mineralized structures, it is likely that the
                      soft organic matrix is crucial for absorbing energy through
                      deformation, irreversible damage, and viscoelastic behavior.
                      In the corpus calcareum, cracks typically terminate toward
                      thick struts along the mineral planes, resembling the
                      microscale crack deflection and arrest mechanism found in
                      other staggered biocomposites, such as nacre or bone. Using
                      transmission electron microscopy (TEM), we observed
                      preferentially oriented, needlelike bioapatite crystallites
                      and d-band patterns of collagen type-II fibrils resulting
                      from intrafibrillar mineralization.},
      cin          = {DOOR ; HAS-User / Hereon},
      ddc          = {540},
      cid          = {I:(DE-H253)HAS-User-20120731 / I:(DE-H253)Hereon-20210428},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3) / FS-Proposal: I-20211443
                      (I-20211443) / FS-Proposal: I-20220547 (I-20220547)},
      pid          = {G:(DE-HGF)POF4-6G3 / G:(DE-H253)I-20211443 /
                      G:(DE-H253)I-20220547},
      experiment   = {EXP:(DE-H253)P-P05-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40191917},
      doi          = {10.1021/acsnano.5c02004},
      url          = {https://bib-pubdb1.desy.de/record/634681},
}