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@ARTICLE{Zhou:633011,
      author       = {Zhou, Weijun and Strmšek, Žiga and Snoj, Jaka and
                      Škarabot, Miha and Jerala, Roman},
      title        = {{P}rogrammable {P}rotein‐{DNA} {C}omposite
                      {N}anostructures: from {N}anostructure {C}onstruction to
                      {P}rotein‐{I}nduced {M}icro‐{S}cale {M}aterial
                      {S}elf‐{A}ssembly and {F}unctionalization},
      journal      = {Small},
      volume       = {21},
      number       = {30},
      issn         = {1613-6810},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {PUBDB-2025-02337},
      pages        = {2502060},
      year         = {2025},
      abstract     = {The integration of DNA and protein-designed nanostructures
                      represents a transformative approach to the development of
                      programmable biopolymers for nanoscale construction. While
                      DNA nanostructures excel in the readily programmable
                      precision and scalability of base pairing, protein
                      assemblies exploit the chemical diversity of amino acids for
                      greater functional versatility. Here a platform is presented
                      that unifies these two paradigms by combining coiled-coil
                      protein origami with DNA nanostructures through orthogonal
                      protein-protein (SpyCatcher-SpyTag) and protein-DNA
                      (DCV-DNA) covalent conjugation strategies. This
                      dual-functionalization strategy enables the construction of
                      stable and versatile protein-DNA composites capable of
                      hierarchical self-assembly. This shows that these composites
                      drive the transformation of DNA nanotubes into large-scale,
                      patterned nanofibers or nanorods, with the proteins
                      regularly distributed over their surface and retaining their
                      enzymatic and fluorescent functions. In addition, a
                      DNA-luciferase circuit is developed through split enzyme
                      reconstitution to achieve reversible regulation of enzymatic
                      activity, highlighting the dynamic functionality of these
                      composites. This introduces a modular approach to producing
                      multifunctional bio-nanomaterials, highlighting the
                      potential of protein-DNA composite nanostructures as a
                      bridge between molecular design and functional nanomaterials
                      and paves the way for the development of dynamic bio-devices
                      and programmable biomaterials.},
      cin          = {EMBL-User},
      ddc          = {620},
      cid          = {I:(DE-H253)EMBL-User-20120814},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3) / LoopOfFun - Closed-loop
                      control of fungal materials (101070817)},
      pid          = {G:(DE-HGF)POF4-6G3 / G:(EU-Grant)101070817},
      experiment   = {EXP:(DE-H253)P-P12-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40442952},
      doi          = {10.1002/smll.202502060},
      url          = {https://bib-pubdb1.desy.de/record/633011},
}