TY  - JOUR
AU  - Myllykoski, Matti
AU  - Lundekvam, Malin
AU  - Osberg, Camilla
AU  - Nilsen, Solveig Siqveland
AU  - Arnesen, Thomas
TI  - The molecular basis for acetylhistidine synthesis by HisAT/NAT16
JO  - Nature Communications
VL  - 16
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Springer Nature
M1  - PUBDB-2025-02331
SP  - 5960
PY  - 2025
AB  - Acetylhistidine has been detected in human blood, but its origin and function are not known. It is formed when the acetyl group of acetyl-CoA is transferred to the α-amino group of histidine. Here we identify the intracellular NAT16 as the human histidine acetyltransferase (HisAT) responsible for histidine acetylation in vitro and in vivo. A NAT16 variant (p.Phe63Ser) present in over 5
LB  - PUB:(DE-HGF)16
C6  - pmid:40595645
DO  - DOI:10.1038/s41467-025-61145-x
UR  - https://bib-pubdb1.desy.de/record/633005
ER  -