%0 Journal Article
%A Myllykoski, Matti
%A Lundekvam, Malin
%A Osberg, Camilla
%A Nilsen, Solveig Siqveland
%A Arnesen, Thomas
%T The molecular basis for acetylhistidine synthesis by HisAT/NAT16
%J Nature Communications
%V 16
%N 1
%@ 2041-1723
%C [London]
%I Springer Nature
%M PUBDB-2025-02331
%P 5960
%D 2025
%X Acetylhistidine has been detected in human blood, but its origin and function are not known. It is formed when the acetyl group of acetyl-CoA is transferred to the α-amino group of histidine. Here we identify the intracellular NAT16 as the human histidine acetyltransferase (HisAT) responsible for histidine acetylation in vitro and in vivo. A NAT16 variant (p.Phe63Ser) present in over 5
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40595645
%R 10.1038/s41467-025-61145-x
%U https://bib-pubdb1.desy.de/record/633005