TY  - JOUR
AU  - Lin, Sheng-Chih
AU  - Ahmedi, Sihana
AU  - Kretschmer, Aaron
AU  - Campalani, Carlotta
AU  - Kayser, Yves
AU  - Kang, Liqun
AU  - DeBeer, Serena
AU  - Leitner, Walter
AU  - Bordet, Alexis
TI  - Low pressure amide hydrogenation enabled by magnetocatalysis
JO  - Nature Communications
VL  - 16
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Springer Nature
M1  - PUBDB-2025-02323
SP  - 3464
PY  - 2025
AB  - The catalytic hydrogenation of amides with molecular hydrogen (H2) is an appealing route for the synthesis of valuable amines entering in the preparation of countless organic compounds. Running effective amide hydrogenation under mild H2 pressures is challenging although desirable to preclude the need for specialized high-pressure technologies in research and industry. Here we show that magnetocatalysis with standard supported catalysts enables unprecedented amide hydrogenation at mild conditions. Widely available and commercial platinum on alumina (Pt/Al2O3) was functionalized with iron carbide nanoparticles (ICNPs) to allow for localized and rapid magnetic induction heating resulting in the activation of neighboring Pt sites by thermal energy transfer. Exposure of the ICNPs@Pt/Al2O3 catalyst to an alternating current magnetic field enables highly active and selective hydrogenation of a range of amides at a reactor temperature of 150 °C under 3 bar or even ambient pressure of H2. ICNPs@Pt/Al2O3 reacts adaptively to fluctuations in electricity supply mimicking the use of intermittent renewable energy sources. This work may pave the way toward a greatly enhanced practicability of amide hydrogenation at the laboratory and production scales, and demonstrates more generally the broad potential of the emerging field of magnetocatalysis for synthetic chemistry.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1038/s41467-025-58713-6
UR  - https://bib-pubdb1.desy.de/record/632997
ER  -