Abstract

PUBDB-2025-02253

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Hormone Androsterone vs. Its Analog Decahydro-2-naphthol: Differences and Similarities

Caliebe, S. (Corresponding author)Extern*DESY* ; Pinacho Morante, P.Extern*DESY* ; Schnell, M.CFEL*DESY*

2023

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Please use a persistent id in citations: doi:10.15278/isms.2023.7011

Abstract: Here we report the study on the cis and trans isomers of decahydro-2-naphthol and various complexes with it.Decahydro-2-naphthol is structurally analogous to a section of the steroid hormone androsterone, which has been recently studied by rotational spectroscopy. For the large (from a rotational spectroscopy point of view) molecule androsterone, no experimental gas-phase structure was observed. In addition, intermolecular interactions in complexeswith androsterone and smaller molecules cannot be experimentally studied due to the size of the steroid hormone. Because of that, decahydro-2-naphthol is an excellent system to indicate intermolecular interactions with other molecules and gain knowledge of the experimental gas-phasestructure and thus, the conformational flexibility and arrangement in order to start tounderstand reaction mechanisms and functions of steroid hormones. Further, the orientations of the OH-groups in the decahydro-2-naphthol molecules were determinedand also compared with the results from androsterone. The molecules were studiedin the gas phase in a cold and isolated environment generated by a supersonic expansion. The spectra were recorded using chirped-pulse Fourier transform microwave (CPFTMW) spectroscopy in the 2-8 GHz frequency region. The assignment was supportedby quantum-chemical calculations.

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Contributing Institute(s):

1. Spectroscopy of molecular processes (FS-SMP)

Research Program(s):

1. 631 - Matter – Dynamics, Mechanisms and Control (POF4-631) (POF4-631)

Experiment(s):

1. No specific instrument

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