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@INPROCEEDINGS{Bajt:632808,
      author       = {Bajt, Sasa and Chapman, H. N. and Li, Tang and
                      Fleckenstein, Holger and Prasciolu, M. and Dresselhaus, J.
                      L. and Ivanov, Nikolay and Yefanov, O. and Zhang, Wenhui and
                      Pennicard, D. and Villanueva-Perez, P. and Gutowski, O. and
                      Dippel, A.-C.},
      title        = {{C}ompton microscopy with multilayer {L}aue lenses},
      issn         = {2053-2733},
      reportid     = {PUBDB-2025-02233},
      year         = {2023},
      abstract     = {High resolution X-ray imaging of biological samples is
                      usually limited by radiation damage. One way to overcome
                      this limitation is to work at higher photon energies, where
                      the dominant interaction with matter occurs through
                      inelastic or Compton scattering. We calculated that the
                      signal per dose for imaging biological samples is maximized
                      at about 60 keV [1]. X-ray optics for such high energies
                      were until recently limited to reflective mirrors and
                      refractive compound lenses. However, wedged multilayer Laue
                      lenses (MLLs) [3] offer high efficiency and very high
                      resolution of a few nanometers and only limited by the
                      effective source size and the bandwidth. With our own
                      developed MLLs [4] we performed proof-of-principle
                      experiments and demonstrated scanning Compton X-ray
                      microscopy on biological objects at PETRA III synchrotron
                      [2]. Recently, we optimized this method and obtained low
                      dose images of several dried biological objects. We
                      calibrated the scattering signals using well defined silicon
                      objects, which enabled us to collect quantitative images of
                      the projected densities of the biological objects. Compton
                      microscopy in combination with diffraction-limited X-ray
                      sources and large solid angle detectors have great potential
                      for imaging of un-sectioned and unlabeled cells with lower
                      dose than previously achievable.},
      month         = {Aug},
      date          = {2023-08-22},
      organization  = {Twenty-Sixth Congress and General
                       Assembly of the International Union of
                       Crystallography, Melbourne (Australia),
                       22 Aug 2023 - 29 Aug 2023},
      cin          = {FS-ML / FS-CFEL-1-CFEL / FS-DS / FS-PETRA-D},
      ddc          = {530},
      cid          = {I:(DE-H253)FS-ML-20120731 /
                      I:(DE-H253)FS-CFEL-1-CFEL-20210408 /
                      I:(DE-H253)FS-DS-20120731 / I:(DE-H253)FS-PETRA-D-20210408},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / AIM, DFG project
                      G:(GEPRIS)390715994 - EXC 2056: CUI: Advanced Imaging of
                      Matter (390715994) / FS-Proposal: I-20231280 (I-20231280)},
      pid          = {G:(DE-HGF)POF4-633 / G:(GEPRIS)390715994 /
                      G:(DE-H253)I-20231280},
      experiment   = {EXP:(DE-H253)P-P07-20150101},
      typ          = {PUB:(DE-HGF)1},
      doi          = {10.1107/S205327332309561X},
      url          = {https://bib-pubdb1.desy.de/record/632808},
}