TY  - JOUR
AU  - Deka, Dhruba Jyoti
AU  - Boro, Bishal
AU  - Chen, Yuping
AU  - Chahal, Kapil
AU  - Nandy, Subhajit
AU  - Wang, Caiqi
AU  - Lin, Hongfei
AU  - Tang, Qing
AU  - Mondal, John
TI  - Tyrosinase Enzyme-Inspired Cu(I)-Porous Organic Polymer for Selective Oxidation of Biomass-Derived 5-HMF
JO  - ACS applied materials & interfaces
VL  - 17
IS  - 25
SN  - 1944-8244
CY  - Washington, DC
PB  - Soc.
M1  - PUBDB-2025-02084
SP  - 36840 - 36854
PY  - 2025
AB  - In biobased PET, terephthalic acid (TPA) can be replaced with biobase alternatives like bioderived 5-diformylfuran (DFF). In this work, we have selectively synthesized DFF from the oxidation of 5-hydroxymethylfurfural (HMF) using our tyrosinase enzyme-inspired catalysts vicinal V-Cu-POP and nonvicinal NV-Cu-POP, respectively. Motivated by the oxygenated form of tyrosinase, we introduced binuclear copper(I) moieties into a porous organic polymer to create enzyme-inspired heterogeneous catalysts for the selective oxidation of HMF. V-Cu-POP can effectively activate O<sub>2</sub> for mild and selective oxidation because the two Cu centers are in close proximity, which is impossible in the case of NV-Cu-POP. For the determination of the coordination environment of the catalytically active site, the X-ray absorption near-edge structure (XANES) studies and the copper(I) state for both the enzyme-inspired catalysts V-Cu-POP and NV-Cu-POP are identified through characteristic features in the absorption spectra. The fitting parameters and EXAFS spectra rule out the formation of the Cu–Cu bond. Further, the key intermediate μ-hydroxy species (Cu (II)–O–O–Cu (II)), which forms during the reaction in the case of the enzyme-inspired catalyst, V-Cu-POP is also confirmed by time-resolved in situ ATR-IR spectroscopy and DFT computational study. This intermediate is not formed in the case of nonvicinal NV-Cu-POP, which is the main reason for lower catalytic activity toward HMF oxidation. NV-Cu-POP still retains the peaks of reactants at the same reaction conditions, which is confirmed by time-resolved in situ ATR-IR spectroscopy. Overall, in this study, we have shown how a tyrosinase enzyme-inspired catalyst exhibits greater catalytic activity toward the oxidation reaction due to the formation of its vicinal conformer compared to the nonvicinal conformer.
LB  - PUB:(DE-HGF)16
C6  - pmid:40512020
DO  - DOI:10.1021/acsami.5c09657
UR  - https://bib-pubdb1.desy.de/record/631969
ER  -