%0 Journal Article
%A Deka, Dhruba Jyoti
%A Boro, Bishal
%A Chen, Yuping
%A Chahal, Kapil
%A Nandy, Subhajit
%A Wang, Caiqi
%A Lin, Hongfei
%A Tang, Qing
%A Mondal, John
%T Tyrosinase Enzyme-Inspired Cu(I)-Porous Organic Polymer for Selective Oxidation of Biomass-Derived 5-HMF
%J ACS applied materials & interfaces
%V 17
%N 25
%@ 1944-8244
%C Washington, DC
%I Soc.
%M PUBDB-2025-02084
%P 36840 - 36854
%D 2025
%X In biobased PET, terephthalic acid (TPA) can be replaced with biobase alternatives like bioderived 5-diformylfuran (DFF). In this work, we have selectively synthesized DFF from the oxidation of 5-hydroxymethylfurfural (HMF) using our tyrosinase enzyme-inspired catalysts vicinal V-Cu-POP and nonvicinal NV-Cu-POP, respectively. Motivated by the oxygenated form of tyrosinase, we introduced binuclear copper(I) moieties into a porous organic polymer to create enzyme-inspired heterogeneous catalysts for the selective oxidation of HMF. V-Cu-POP can effectively activate O<sub>2</sub> for mild and selective oxidation because the two Cu centers are in close proximity, which is impossible in the case of NV-Cu-POP. For the determination of the coordination environment of the catalytically active site, the X-ray absorption near-edge structure (XANES) studies and the copper(I) state for both the enzyme-inspired catalysts V-Cu-POP and NV-Cu-POP are identified through characteristic features in the absorption spectra. The fitting parameters and EXAFS spectra rule out the formation of the Cu–Cu bond. Further, the key intermediate μ-hydroxy species (Cu (II)–O–O–Cu (II)), which forms during the reaction in the case of the enzyme-inspired catalyst, V-Cu-POP is also confirmed by time-resolved in situ ATR-IR spectroscopy and DFT computational study. This intermediate is not formed in the case of nonvicinal NV-Cu-POP, which is the main reason for lower catalytic activity toward HMF oxidation. NV-Cu-POP still retains the peaks of reactants at the same reaction conditions, which is confirmed by time-resolved in situ ATR-IR spectroscopy. Overall, in this study, we have shown how a tyrosinase enzyme-inspired catalyst exhibits greater catalytic activity toward the oxidation reaction due to the formation of its vicinal conformer compared to the nonvicinal conformer.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40512020
%R 10.1021/acsami.5c09657
%U https://bib-pubdb1.desy.de/record/631969