TY  - JOUR
AU  - Dalloul, Feras
AU  - Mietner, J. Benedikt
AU  - Raveendran, Dhanya
AU  - Chen, Shouzheng
AU  - Barba, Enguerrand
AU  - Möck, Dennis M. J.
AU  - Hubel, Fabio
AU  - Sochor, Benedikt
AU  - Koyiloth Vayalil, Sarathlal
AU  - Hesse, Linnea
AU  - Olbrich, Andrea
AU  - Appelt, Jörn
AU  - Müller-Buschbaum, Peter
AU  - Roth, Stephan V.
AU  - Navarro, Julien R.G.
TI  - From Unprintable Peptidic Gel to Unstoppable: Transforming Diphenylalanine Peptide (Fmoc-FF) Nanowires and Cellulose Nanofibrils into a High-Performance Biobased Gel for 3D Printing
JO  - ACS applied bio materials
VL  - 8
IS  - 3
SN  - 2576-6422
CY  - Washington, DC
PB  - ACS Publications
M1  - PUBDB-2025-01941
SP  - 2323 - 2339
PY  - 2025
AB  - The growing interest in gel-based additive manufacturing, also known as three-dimensional (3D) gel-printing technology, for research underscores the crucial need to develop robust biobased materials with excellent printing quality and reproducibility. The main focus of this study is to prepare and characterize some composite gels obtained with a low-molecular-weight gelling (LMWG) peptide called Fmoc-diphenylalanine (Fmoc-FF) and two types of cellulose nanofibrils (CNFs). The so-called Fmoc-FF peptide has the ability to self-assemble into a nanowire shape and therefore create an organized network that induces the formation of a gel. Despite their ease of preparation and potential use in biological systems, unfortunately, those Fmoc-FF nanowire gel systems cannot be 3D printed due to the high stiffness of the gel. For this reason, this study focuses on composite materials made of cellulose nanofibrils and Fmoc-FF nanowires, with the main objective being that the composite gels will be suitable for 3D printing applications. Two types of cellulose nanofibrils are employed in this study: (1) unmodified pristine cellulose nanofibrils (uCNF) and (2) chemically modified cellulose nanofibrils, which ones have been grafted with polymers containing the Fmoc unit on their backbone (CNF-g-Fmoc). The obtained products were characterized through solid-state cross-polarization magic angle-spinning 1H NMR and confocal laser scanning microscopy. Within these two CNF structures, two composite gels were produced: uCNF/Fmoc-FF and CNF-g-Fmoc/Fmoc-FF. The mechanical properties and printability of the composites are assessed using rheology and challenging 3D object printing. With the addition of water, different properties of the gels were observed. In this instance, CNF-g-Fmoc/Fmoc-FF (c = 5.1
LB  - PUB:(DE-HGF)16
C6  - pmid:40051331
DO  - DOI:10.1021/acsabm.4c01803
UR  - https://bib-pubdb1.desy.de/record/631269
ER  -