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@ARTICLE{Brezesinski:630061,
      author       = {Brezesinski, Gerald and Opálka, Lukáš and Shen, Chen and
                      Groetzsch, Carolin and Schneck, Emanuel and Eichner, Adina},
      title        = {{S}tructure–{F}unction {R}elationship of the {M}ost
                      {A}bundant {C}eramide {S}ubspecies {S}tudied on {M}onolayer
                      {M}odels {U}sing {GIXD} and {L}angmuir {I}sotherms},
      journal      = {Langmuir},
      volume       = {41},
      number       = {22},
      issn         = {0743-7463},
      address      = {Washington, DC},
      publisher    = {ACS Publ.},
      reportid     = {PUBDB-2025-01836},
      pages        = {14255 - 14264},
      year         = {2025},
      abstract     = {The main lipid compounds of the outermost layer of human
                      skin are ceramides (CERs), free fatty acids, and
                      cholesterol. Although numerous studies performed in the past
                      could demonstrate the importance of these lipids for an
                      intact skin barrier function, knowledge about the impact of
                      each single component on the lamellar lipid films is still
                      lacking. Especially, the CERs are a very heterogeneous group
                      with high relevance for a proper barrier. It was found that
                      the reason for the high stability of the lamellae is related
                      to the lipid structure and function, with the type and
                      extent of interactions between the head groups of the
                      individual CER subspecies being particularly important.
                      Elucidating these at the molecular level could help us to
                      understand CER phase behavior in general. Using grazing
                      incidence X-ray diffraction and measurements of Langmuir
                      isotherms, the current work investigated the lateral packing
                      of the monolayers of different subclasses of C18:0 CERs at
                      air–water interfaces, including phytosphingosine,
                      sphingosine, and dihydrosphingosine CERs, all with either
                      α-hydroxy and nonhydroxy N-acylated fatty acyl. We were
                      able to observe clear effects of the minimal differences in
                      the polar headgroup structures of the sphingoid bases, with
                      respect to the number and position of hydroxyl groups and
                      double bonds, on the CER arrangement regarding the
                      compressibility and structure of the films they formed,
                      revealing that the hydroxyl group at the C4 of the
                      phytosphingosine CERs leads not only to the formation of a
                      hydrogen bond network but also to a stable suprastructure,
                      which might be of high benefit for the barrier properties of
                      intact skin.},
      cin          = {FS DOOR-User / FS-PET-D},
      ddc          = {540},
      cid          = {$I:(DE-H253)FS_DOOR-User-20241023$ /
                      I:(DE-H253)FS-PET-D-20190712},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P08-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40424481},
      UT           = {WOS:001497475300001},
      doi          = {10.1021/acs.langmuir.5c01340},
      url          = {https://bib-pubdb1.desy.de/record/630061},
}