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@ARTICLE{Strati:629254,
      author       = {Strati, Fabio and Drescher, Simon and Shen, Chen and
                      Neubert, Reinhard H. H. and Brezesinski, Gerald},
      title        = {{H}ydrogenated plant-based lecithins as excipients for
                      cosmetic and pharmaceutical applications: {A}
                      physical-chemical study},
      journal      = {European journal of pharmaceutical sciences},
      volume       = {211},
      issn         = {0928-0987},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {PUBDB-2025-01782},
      pages        = {107144},
      year         = {2025},
      abstract     = {Lecithin is a generic term that is often used to indicate a
                      product mainly constituted of phospholipids. Lecithins can
                      be used in pharmaceutical and cosmetic field as wetting
                      agents, emulsifiers and building blocks for the production
                      of liposomes and micelles. One of its main sources are
                      plants. From their extraction a final product mainly
                      constituted of phosphatidylcholines and
                      phosphatidylethanolamines can be obtained. Common issue
                      connected to freshly extracted lecithins is the presence of
                      a product rich in double bonds subject to photo and air
                      oxidation. By adding in the purification process a further
                      catalytic step, it is possible to form stable hydrogenated
                      lecithin products. Despite their widespread use, little is
                      known about the physicochemical properties of such
                      hydrogenated lecithins, detailed studies mainly based on
                      X-ray scattering methods on mono- and multi-layers have been
                      performed. Additionally, the emulsifying properties of these
                      lecithins such as Hydrophilic-Lipophilic Deviation (HLD
                      parameter) and solubility have also been studied. General
                      findings are that mixtures with higher amounts of
                      phosphatidylcholines (90–100 $\%)$ formed a well-defined
                      lamellar phase showing in monolayers complete absence of
                      charge, while lecithins with lower phosphatidylcholine
                      contents (75–80 $\%)$ formed charged monolayers and
                      positionally uncorrelated bilayers due to the presence of
                      charged species. The hydrogenated phospholipids (PLs)
                      studied were highly soluble in several co-solvents which are
                      suitable for the incorporation of these phospholipids into
                      relevant dermal formulations. The studied PLs are able to
                      stabilize innovative dermal colloidal formulations such as
                      cerosomes and to improve the incorporation of them into
                      Stratum corneum models.In conclusion, the following studies
                      will allow a more rational selection of hydrogenated
                      lecithins for the formulation of cosmetic and pharmaceutical
                      products.},
      cin          = {FS DOOR-User / FS-PET-D},
      ddc          = {610},
      cid          = {$I:(DE-H253)FS_DOOR-User-20241023$ /
                      I:(DE-H253)FS-PET-D-20190712},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)
                      / FS-Proposal: I-20190800 (I-20190800)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3 /
                      G:(DE-H253)I-20190800},
      experiment   = {EXP:(DE-H253)P-P08-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40425131},
      UT           = {WOS:001504428300001},
      doi          = {10.1016/j.ejps.2025.107144},
      url          = {https://bib-pubdb1.desy.de/record/629254},
}