TY  - JOUR
AU  - Strati, Fabio
AU  - Drescher, Simon
AU  - Shen, Chen
AU  - Neubert, Reinhard H. H.
AU  - Brezesinski, Gerald
TI  - Hydrogenated plant-based lecithins as excipients for cosmetic and pharmaceutical applications: A physical-chemical study
JO  - European journal of pharmaceutical sciences
VL  - 211
SN  - 0928-0987
CY  - New York, NY [u.a.]
PB  - Elsevier
M1  - PUBDB-2025-01782
SP  - 107144
PY  - 2025
AB  - Lecithin is a generic term that is often used to indicate a product mainly constituted of phospholipids. Lecithins can be used in pharmaceutical and cosmetic field as wetting agents, emulsifiers and building blocks for the production of liposomes and micelles. One of its main sources are plants. From their extraction a final product mainly constituted of phosphatidylcholines and phosphatidylethanolamines can be obtained. Common issue connected to freshly extracted lecithins is the presence of a product rich in double bonds subject to photo and air oxidation. By adding in the purification process a further catalytic step, it is possible to form stable hydrogenated lecithin products. Despite their widespread use, little is known about the physicochemical properties of such hydrogenated lecithins, detailed studies mainly based on X-ray scattering methods on mono- and multi-layers have been performed. Additionally, the emulsifying properties of these lecithins such as Hydrophilic-Lipophilic Deviation (HLD parameter) and solubility have also been studied. General findings are that mixtures with higher amounts of phosphatidylcholines (90–100 
LB  - PUB:(DE-HGF)16
C6  - 40425131
UR  - <Go to ISI:>//WOS:001504428300001
DO  - DOI:10.1016/j.ejps.2025.107144
UR  - https://bib-pubdb1.desy.de/record/629254
ER  -