000629254 001__ 629254
000629254 005__ 20250715151529.0
000629254 0247_ $$2doi$$a10.1016/j.ejps.2025.107144
000629254 0247_ $$2ISSN$$a0928-0987
000629254 0247_ $$2ISSN$$a1879-0720
000629254 0247_ $$2datacite_doi$$a10.3204/PUBDB-2025-01782
000629254 0247_ $$2pmid$$a40425131
000629254 0247_ $$2WOS$$aWOS:001504428300001
000629254 0247_ $$2openalex$$aopenalex:W4410759051
000629254 037__ $$aPUBDB-2025-01782
000629254 041__ $$aEnglish
000629254 082__ $$a610
000629254 1001_ $$0P:(DE-H253)PIP1087741$$aStrati, Fabio$$b0
000629254 245__ $$aHydrogenated plant-based lecithins as excipients for cosmetic and pharmaceutical applications: A physical-chemical study
000629254 260__ $$aNew York, NY [u.a.]$$bElsevier$$c2025
000629254 3367_ $$2DRIVER$$aarticle
000629254 3367_ $$2DataCite$$aOutput Types/Journal article
000629254 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1752235489_3135729
000629254 3367_ $$2BibTeX$$aARTICLE
000629254 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000629254 3367_ $$00$$2EndNote$$aJournal Article
000629254 520__ $$aLecithin is a generic term that is often used to indicate a product mainly constituted of phospholipids. Lecithins can be used in pharmaceutical and cosmetic field as wetting agents, emulsifiers and building blocks for the production of liposomes and micelles. One of its main sources are plants. From their extraction a final product mainly constituted of phosphatidylcholines and phosphatidylethanolamines can be obtained. Common issue connected to freshly extracted lecithins is the presence of a product rich in double bonds subject to photo and air oxidation. By adding in the purification process a further catalytic step, it is possible to form stable hydrogenated lecithin products. Despite their widespread use, little is known about the physicochemical properties of such hydrogenated lecithins, detailed studies mainly based on X-ray scattering methods on mono- and multi-layers have been performed. Additionally, the emulsifying properties of these lecithins such as Hydrophilic-Lipophilic Deviation (HLD parameter) and solubility have also been studied. General findings are that mixtures with higher amounts of phosphatidylcholines (90–100 %) formed a well-defined lamellar phase showing in monolayers complete absence of charge, while lecithins with lower phosphatidylcholine contents (75–80 %) formed charged monolayers and positionally uncorrelated bilayers due to the presence of charged species. The hydrogenated phospholipids (PLs) studied were highly soluble in several co-solvents which are suitable for the incorporation of these phospholipids into relevant dermal formulations. The studied PLs are able to stabilize innovative dermal colloidal formulations such as cerosomes and to improve the incorporation of them into Stratum corneum models.In conclusion, the following studies will allow a more rational selection of hydrogenated lecithins for the formulation of cosmetic and pharmaceutical products.
000629254 536__ $$0G:(DE-HGF)POF4-633$$a633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633)$$cPOF4-633$$fPOF IV$$x0
000629254 536__ $$0G:(DE-HGF)POF4-6G3$$a6G3 - PETRA III (DESY) (POF4-6G3)$$cPOF4-6G3$$fPOF IV$$x1
000629254 536__ $$0G:(DE-H253)I-20190800$$aFS-Proposal: I-20190800 (I-20190800)$$cI-20190800$$x2
000629254 588__ $$aDataset connected to CrossRef, Journals: bib-pubdb1.desy.de
000629254 693__ $$0EXP:(DE-H253)P-P08-20150101$$1EXP:(DE-H253)PETRAIII-20150101$$6EXP:(DE-H253)P-P08-20150101$$aPETRA III$$fPETRA Beamline P08$$x0
000629254 7001_ $$0P:(DE-H253)PIP1019534$$aDrescher, Simon$$b1
000629254 7001_ $$0P:(DE-H253)PIP1014115$$aShen, Chen$$b2
000629254 7001_ $$0P:(DE-H253)PIP1092617$$aNeubert, Reinhard H. H.$$b3
000629254 7001_ $$0P:(DE-H253)PIP1008088$$aBrezesinski, Gerald$$b4$$eCorresponding author
000629254 773__ $$0PERI:(DE-600)1483522-8$$a10.1016/j.ejps.2025.107144$$gVol. 211, p. 107144 -$$p107144$$tEuropean journal of pharmaceutical sciences$$v211$$x0928-0987$$y2025
000629254 8564_ $$uhttps://bib-pubdb1.desy.de/record/629254/files/1-s2.0-S0928098725001435-main.pdf$$yOpenAccess
000629254 8564_ $$uhttps://bib-pubdb1.desy.de/record/629254/files/1-s2.0-S0928098725001435-main.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000629254 909CO $$ooai:bib-pubdb1.desy.de:629254$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000629254 9101_ $$0I:(DE-588b)2008985-5$$6P:(DE-H253)PIP1087741$$aDeutsches Elektronen-Synchrotron$$b0$$kDESY
000629254 9101_ $$0I:(DE-H253)_CSSB-20140311$$6P:(DE-H253)PIP1087741$$aCentre for Structural Systems Biology$$b0$$kCSSB
000629254 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1087741$$aExternal Institute$$b0$$kExtern
000629254 9101_ $$0I:(DE-588b)235011-7$$6P:(DE-H253)PIP1019534$$aEuropean Molecular Biology Laboratory$$b1$$kEMBL
000629254 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1019534$$aExternal Institute$$b1$$kExtern
000629254 9101_ $$0I:(DE-588b)2008985-5$$6P:(DE-H253)PIP1014115$$aDeutsches Elektronen-Synchrotron$$b2$$kDESY
000629254 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1014115$$aExternal Institute$$b2$$kExtern
000629254 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1092617$$aExternal Institute$$b3$$kExtern
000629254 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1008088$$aExternal Institute$$b4$$kExtern
000629254 9131_ $$0G:(DE-HGF)POF4-633$$1G:(DE-HGF)POF4-630$$2G:(DE-HGF)POF4-600$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bForschungsbereich Materie$$lVon Materie zu Materialien und Leben$$vLife Sciences – Building Blocks of Life: Structure and Function$$x0
000629254 9131_ $$0G:(DE-HGF)POF4-6G3$$1G:(DE-HGF)POF4-6G0$$2G:(DE-HGF)POF4-600$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bForschungsbereich Materie$$lGroßgeräte: Materie$$vPETRA III (DESY)$$x1
000629254 9141_ $$y2025
000629254 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)1200$$2StatID$$aDBCoverage$$bChemical Reactions$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2022-09-16T14:28:48Z
000629254 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2022-09-16T14:28:48Z
000629254 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2024-12-13$$wger
000629254 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bEUR J PHARM SCI : 2022$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)1210$$2StatID$$aDBCoverage$$bIndex Chemicus$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000629254 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-13
000629254 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000629254 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-13
000629254 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-13
000629254 9201_ $$0I:(DE-H253)FS_DOOR-User-20241023$$kFS DOOR-User$$lFS DOOR-User$$x0
000629254 9201_ $$0I:(DE-H253)FS-PET-D-20190712$$kFS-PET-D$$lExperimentebetreuung PETRA III$$x1
000629254 980__ $$ajournal
000629254 980__ $$aVDB
000629254 980__ $$aI:(DE-H253)FS_DOOR-User-20241023
000629254 980__ $$aI:(DE-H253)FS-PET-D-20190712
000629254 980__ $$aUNRESTRICTED
000629254 9801_ $$aFullTexts