%0 Journal Article
%A Strati, Fabio
%A Drescher, Simon
%A Shen, Chen
%A Neubert, Reinhard H. H.
%A Brezesinski, Gerald
%T Hydrogenated plant-based lecithins as excipients for cosmetic and pharmaceutical applications: A physical-chemical study
%J European journal of pharmaceutical sciences
%V 211
%@ 0928-0987
%C New York, NY [u.a.]
%I Elsevier
%M PUBDB-2025-01782
%P 107144
%D 2025
%X Lecithin is a generic term that is often used to indicate a product mainly constituted of phospholipids. Lecithins can be used in pharmaceutical and cosmetic field as wetting agents, emulsifiers and building blocks for the production of liposomes and micelles. One of its main sources are plants. From their extraction a final product mainly constituted of phosphatidylcholines and phosphatidylethanolamines can be obtained. Common issue connected to freshly extracted lecithins is the presence of a product rich in double bonds subject to photo and air oxidation. By adding in the purification process a further catalytic step, it is possible to form stable hydrogenated lecithin products. Despite their widespread use, little is known about the physicochemical properties of such hydrogenated lecithins, detailed studies mainly based on X-ray scattering methods on mono- and multi-layers have been performed. Additionally, the emulsifying properties of these lecithins such as Hydrophilic-Lipophilic Deviation (HLD parameter) and solubility have also been studied. General findings are that mixtures with higher amounts of phosphatidylcholines (90–100 
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 40425131
%U <Go to ISI:>//WOS:001504428300001
%R 10.1016/j.ejps.2025.107144
%U https://bib-pubdb1.desy.de/record/629254