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@ARTICLE{Steinbrueck:627908,
      author       = {Steinbrueck, Axel and Reback, Matthew L. and Rumancev,
                      Christoph and Siegmund, Daniel and Garrevoet, Jan and
                      Falkenberg, Gerald and Rosenhahn, Axel and Prokop, Aram and
                      Metzler-Nolte, Nils},
      title        = {{Q}uinizarin {G}old({I}) {N}‐{H}eterocyclic {C}arbene
                      {C}omplexes with {S}ynergistic {A}ctivity {A}gainst
                      {A}nthracycline‐{R}esistant {L}eukaemia {C}ells:
                      {S}ynthesis and {B}iological {A}ctivity {S}tudies},
      journal      = {Chemistry - a European journal},
      volume       = {31},
      number       = {11},
      issn         = {0947-6539},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {PUBDB-2025-01683},
      pages        = {e202404147},
      year         = {2025},
      abstract     = {New, asymmetric quinizarin-Au(I)-NHC complexes were
                      designed, isolated, and fully characterised including by
                      single crystal X-ray crystallography. Cytotoxicity studies
                      showed effective growth inhibition in HeLa cervical cancer
                      cells with IC$_{50}$ values ranging from 2.4 μM to
                      5.3 μM. The successful cellular uptake was evidenced by
                      X-ray fluorescence imaging on cryo-preserved whole HeLa
                      cells and the sub-cellular localisation was monitored by
                      live-cell fluorescence microscopy. Notably, complex 2 b
                      showed circumvention of acquired anthracycline resistance in
                      K562 leukaemia cells as well as synergistic activity with
                      doxorubicin against both wild-type and
                      anthracycline-resistant Nalm-6 leukaemia cells.
                      Interestingly, sub-cellular localisation towards
                      mitochondria proved to be more important than the
                      compounds’ overall cytotoxicity for potent
                      antiproliferative activity and to achieve effective
                      resistance circumvention.},
      organization  = {XXIX. International Conference on
                       Coordination and Bioinorganic
                       Chemistry, Bratislava (Slovakia)},
      cin          = {FS DOOR-User / FS-PET-S},
      ddc          = {660},
      cid          = {$I:(DE-H253)FS_DOOR-User-20241023$ /
                      I:(DE-H253)FS-PET-S-20190712},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)
                      / DFG project G:(GEPRIS)518777768 - Entwicklung von Sonden
                      für das selektive Anfärben intrazellulärer Organelle in
                      der Röntgenfluoreszenzspektroskopie von menschlichen Zell-
                      und Gewebeproben (518777768)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3 /
                      G:(GEPRIS)518777768},
      experiment   = {EXP:(DE-H253)P-P06-20150101},
      typ          = {PUB:(DE-HGF)8 / PUB:(DE-HGF)16},
      pubmed       = {pmid:39757433},
      UT           = {WOS:001389875200001},
      doi          = {10.1002/chem.202404147},
      url          = {https://bib-pubdb1.desy.de/record/627908},
}