TY  - JOUR
AU  - Steinbrueck, Axel
AU  - Reback, Matthew L.
AU  - Rumancev, Christoph
AU  - Siegmund, Daniel
AU  - Garrevoet, Jan
AU  - Falkenberg, Gerald
AU  - Rosenhahn, Axel
AU  - Prokop, Aram
AU  - Metzler-Nolte, Nils
TI  - Quinizarin Gold(I) N‐Heterocyclic Carbene Complexes with Synergistic Activity Against Anthracycline‐Resistant Leukaemia Cells: Synthesis and Biological Activity Studies
JO  - Chemistry - a European journal
VL  - 31
IS  - 11
SN  - 0947-6539
CY  - Weinheim
PB  - Wiley-VCH
M1  - PUBDB-2025-01683
SP  - e202404147
PY  - 2025
AB  - New, asymmetric quinizarin-Au(I)-NHC complexes were designed, isolated, and fully characterised including by single crystal X-ray crystallography. Cytotoxicity studies showed effective growth inhibition in HeLa cervical cancer cells with IC<sub>50</sub> values ranging from 2.4 μM to 5.3 μM. The successful cellular uptake was evidenced by X-ray fluorescence imaging on cryo-preserved whole HeLa cells and the sub-cellular localisation was monitored by live-cell fluorescence microscopy. Notably, complex 2 b showed circumvention of acquired anthracycline resistance in K562 leukaemia cells as well as synergistic activity with doxorubicin against both wild-type and anthracycline-resistant Nalm-6 leukaemia cells. Interestingly, sub-cellular localisation towards mitochondria proved to be more important than the compounds’ overall cytotoxicity for potent antiproliferative activity and to achieve effective resistance circumvention. 
T2  - XXIX. International Conference on Coordination and Bioinorganic Chemistry
CY  - , Bratislava (Slovakia)
M2  - Bratislava, Slovakia
LB  - PUB:(DE-HGF)8 ; PUB:(DE-HGF)16
C6  - pmid:39757433
UR  - <Go to ISI:>//WOS:001389875200001
DO  - DOI:10.1002/chem.202404147
UR  - https://bib-pubdb1.desy.de/record/627908
ER  -