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@ARTICLE{BlancoGarcia:626716,
author = {Blanco Garcia, Miguel and Perilli, Daniele and Daldossi,
Chiara and Ugolotti, Aldo and Giordano, Marta and Dolling,
Silvan and Wagstaffe, Michael and Kohantorabi, Mona and
Stierle, Andreas and Di Valentin, Cristiana and Noei,
Heshmat},
title = {{U}nravelling the {R}ole of the {M}ulti-{F}unctional
{G}roups in the {A}dsorption of {L}-{C}ysteine on {R}utile
{T}i{O}₂(110)},
journal = {Journal of the American Chemical Society},
volume = {147},
number = {44},
issn = {0002-7863},
address = {Washington, DC},
publisher = {ACS Publications},
reportid = {PUBDB-2025-01513},
pages = {40158 - 40170},
year = {2025},
abstract = {Understanding the interaction between biomolecules and
oxide surfaces is essential for advancing technologies in
photocatalysis, virus inactivation, and self-cleaning
materials. This study investigates the adsorption behavior
of L-cysteine on the rutile TiO₂(110) surface using a
combined experimental and theoretical approach. By employing
X-ray photoelectron spectroscopy (XPS), Fourier-transform
infrared reflection absorption spectroscopy (FT-IRRAS),
scanning tunneling microscopy (STM), and density functional
theory (DFT) calculations, we elucidate the molecular
configurations and bonding mechanisms involved in the
interaction of cysteine with the TiO₂ surface. The results
reveal three distinct adsorption geometries: two bidentate
bridging modes involving the carboxylate group and amino
group and a configuration involving the interaction of the
thiolate group with titanium atoms. Additionally, at higher
coverages, cysteine molecules form dimers stabilized by
disulfide bonds, while maintaining a zwitterionic state. Our
study highlights, for the first time, the key role of the
thiol group in cysteine adsorption on TiO2, both for surface
direct binding and dimer formation. These findings provide
new insights into the fundamental principles of
biomolecule-semiconductor interactions, with important
implications for surface-functionalized materials in
catalysis and sensing.},
cin = {FS-NL},
ddc = {540},
cid = {I:(DE-H253)FS-NL-20120731},
pnm = {632 - Materials – Quantum, Complex and Functional
Materials (POF4-632)},
pid = {G:(DE-HGF)POF4-632},
experiment = {EXP:(DE-H253)Nanolab-02-20150101 /
EXP:(DE-H253)Nanolab-01-20150101},
typ = {PUB:(DE-HGF)16},
doi = {10.1021/jacs.5c07119},
url = {https://bib-pubdb1.desy.de/record/626716},
}