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| 001 | 626508 | ||
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| 024 | 7 | _ | |a 10.1111/febs.17405 |2 doi |
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| 100 | 1 | _ | |a Jansen, Séverine |0 0000-0002-1438-4573 |b 0 |
| 245 | _ | _ | |a Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ |
| 260 | _ | _ | |a Oxford [u.a.] |c 2025 |b Wiley-Blackwell |
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| 520 | _ | _ | |a Microtubule associated protein 2 (MAP2) interacts with the regulatory protein 14-3-3ζ in a cAMP-dependent protein kinase (PKA) phosphorylation dependent manner. Using selective phosphorylation, calorimetry, nuclear magnetic resonance, chemical crosslinking, and X-ray crystallography, we characterized interactions of 14-3-3ζ with various binding regions of MAP2c. Although PKA phosphorylation increases the affinity of MAP2c for 14-3-3ζ in the proline rich region and C-terminal domain, unphosphorylated MAP2c also binds the dimeric 14-3-3ζ via its microtubule binding domain and variable central domain. Monomerization of 14-3-3ζ leads to the loss of affinity for the unphosphorylated residues. In neuroblastoma cell extract, MAP2c is heavily phosphorylated by PKA and the proline kinase ERK2. Although 14-3-3ζ dimer or monomer do not interact with the residues phosphorylated by ERK2, ERK2 phosphorylation of MAP2c in the C-terminal domain reduces the binding of MAP2c to both oligomeric variants of 14-3-3ζ. |
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| 700 | 1 | _ | |a Narasimhan, Subhash |b 1 |
| 700 | 1 | _ | |a Cabre Fernandez, Paula |b 2 |
| 700 | 1 | _ | |a Iľkovičová, Lucia |b 3 |
| 700 | 1 | _ | |a Kozeleková, Aneta |b 4 |
| 700 | 1 | _ | |a Králová, Kateřina |b 5 |
| 700 | 1 | _ | |a Hritz, Jozef |0 0000-0002-4512-9241 |b 6 |
| 700 | 1 | _ | |a Žídek, Lukáš |0 P:(DE-HGF)0 |b 7 |e Corresponding author |
| 773 | _ | _ | |a 10.1111/febs.17405 |g Vol. 292, no. 8, p. 1991 - 2016 |0 PERI:(DE-600)2172518-4 |n 8 |p 1991 - 2016 |t The FEBS journal |v 292 |y 2025 |x 0014-2956 |
| 856 | 4 | _ | |u https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.17405 |
| 856 | 4 | _ | |u https://bib-pubdb1.desy.de/record/626508/files/Characterization%20of%20multiple%20binding%20sites%20on%20microtubule%20associated%20protein%202c%20recognized%20by%20dimeric%20and%20monomeric%2014%E2%80%903%E2%80%903.pdf |y OpenAccess |
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