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000626504 1001_ $$0P:(DE-HGF)0$$aBukhdruker, Sergey$$b0
000626504 245__ $$aProteorhodopsin insights into the molecular mechanism of vectorial proton transport
000626504 260__ $$aWashington, DC [u.a.]$$bAssoc.$$c2025
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000626504 520__ $$aBacterial proton pumps, proteorhodopsins (PRs), are a major group of light-driven membrane proteins found in marine bacteria. They are functionally and structurally distinct from archaeal and eukaryotic proton pumps. To elucidate the proton transfer mechanism by PRs and understand the differences to nonbacterial pumps on a molecular level, high-resolution structures of PRs’ functional states are needed. In this work, we have determined atomic-resolution structures of MAR, a PR from marine actinobacteria, in various functional states, notably the challenging late O intermediate state. These data and information from recent atomic-resolution structures on an archaeal outward proton pump bacteriorhodopsin and bacterial inward proton pump xenorhodopsin allow for deducing key universal elements for light-driven proton pumping. First, long hydrogen-bonded chains characterize proton pathways. Second, short hydrogen bonds allow proton storage and inhibit their backflow. Last, the retinal Schiff base is the active proton donor and acceptor to and from hydrogen-bonded chains.
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000626504 7001_ $$0P:(DE-HGF)0$$aGushchin, Ivan$$b1
000626504 7001_ $$0P:(DE-HGF)0$$aShevchenko, Vitaly$$b2
000626504 7001_ $$0P:(DE-HGF)0$$aKovalev, Kirill$$b3
000626504 7001_ $$0P:(DE-HGF)0$$aPolovinkin, Vitaly$$b4
000626504 7001_ $$00000-0001-7422-0899$$aTsybrov, Fedor$$b5
000626504 7001_ $$0P:(DE-HGF)0$$aAstashkin, Roman$$b6
000626504 7001_ $$0P:(DE-HGF)0$$aAlekseev, Alexey$$b7
000626504 7001_ $$00000-0002-4697-0577$$aMikhaylov, Anatoly$$b8
000626504 7001_ $$00000-0002-0770-6597$$aBukhalovich, Siarhei$$b9
000626504 7001_ $$aBratanov, Dmitry$$b10
000626504 7001_ $$0P:(DE-HGF)0$$aRyzhykau, Yury$$b11
000626504 7001_ $$00000-0002-9614-5137$$aKuklina, Daria$$b12
000626504 7001_ $$0P:(DE-HGF)0$$aCaramello, Nicolas$$b13
000626504 7001_ $$00000-0002-7719-1875$$aRokitskaya, Tatyana$$b14
000626504 7001_ $$00000-0002-0244-855X$$aAntonenko, Yuri$$b15
000626504 7001_ $$0P:(DE-HGF)0$$aRulev, Maksim$$b16
000626504 7001_ $$00009-0000-6708-8922$$aStoev, Chavdar$$b17
000626504 7001_ $$0P:(DE-HGF)0$$aZabelskii, Dmitrii$$b18
000626504 7001_ $$aRound, Ekaterina$$b19
000626504 7001_ $$0P:(DE-HGF)0$$aRogachev, Andrey$$b20
000626504 7001_ $$0P:(DE-HGF)0$$aBorshchevskiy, Valentin$$b21
000626504 7001_ $$00000-0002-0591-6152$$aGhai, Rohit$$b22
000626504 7001_ $$0P:(DE-H253)PIP1007425$$aBourenkov, Gleb$$b23
000626504 7001_ $$00000-0003-3686-2510$$aZeghouf, Mahel$$b24
000626504 7001_ $$00000-0002-8966-3067$$aCherfils, Jacqueline$$b25
000626504 7001_ $$aEngelhard, Martin$$b26
000626504 7001_ $$00000-0001-7744-9365$$aChizhov, Igor$$b27
000626504 7001_ $$00000-0002-9809-2059$$aRodriguez-Valera, Francisco$$b28
000626504 7001_ $$0P:(DE-HGF)0$$aBamberg, Ernst$$b29
000626504 7001_ $$0P:(DE-H253)PIP1080706$$aGordeliy, Valentin$$b30$$eCorresponding author
000626504 773__ $$0PERI:(DE-600)2810933-8$$a10.1126/sciadv.adu5303$$gVol. 11, no. 16, p. eadu5303$$n16$$peadu5303$$tScience advances$$v11$$x2375-2548$$y2025
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