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| Home > Publications database > Residual Membrane Fluidity in Mycobacterial Cell Envelope Layers under Extreme Conditions Underlines Membrane-Centric Adaptation > print |
| 001 | 619000 | ||
| 005 | 20250723173023.0 | ||
| 024 | 7 | _ | |a 10.1021/acs.jpcb.4c02469 |2 doi |
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| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 530 |
| 100 | 1 | _ | |a Srivatsav, Aswin T. |0 0000-0003-4218-8585 |b 0 |
| 245 | _ | _ | |a Residual Membrane Fluidity in Mycobacterial Cell Envelope Layers under Extreme Conditions Underlines Membrane-Centric Adaptation |
| 260 | _ | _ | |a Washington, DC |c 2024 |b Americal Chemical Society |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1736935923_3867670 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a Waiting for fulltext |
| 520 | _ | _ | |a One of the routes for adaptation to extreme environments is via remodeling of cell membrane structure, composition, and biophysical properties rendering a functional membrane. Collective studies suggest some form of membrane feedback in mycobacterial species that harbor complex lipids within the outer and inner cell wall layers. Here, we study the homeostatic membrane landscape of mycobacteria in response to high hydrostatic pressure and temperature triggers using high pressure fluorescence, mass and infrared spectroscopies, NMR, SAXS, and molecular dynamics simulations. Our findings reveal that mycobacterial membrane possesses unique and lipid-specific pressure-induced signatures that attenuate progression to highly ordered phases. Both inner and outer membrane layers exhibit phase coexistence of nearly identical lipid phases keeping residual fluidity over a wide range of temperature and pressure, but with different sensitivities. Lipidomic analysis of bacteria grown under pressure revealed lipidome remodeling in terms of chain length, unsaturation, and specific long-chained characteristic mycobacterial lipids, rendering a fluid bacterial membrane. These findings could help understand how bacteria may adapt to a broad spectrum of harsh environments by modulating their lipidome to select lipids that enable the maintenance of a fluid functional cell envelope. |
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| 536 | _ | _ | |a DFG project G:(GEPRIS)390677874 - EXC 2033: RESOLV (Ruhr Explores Solvation) (390677874) |0 G:(GEPRIS)390677874 |c 390677874 |x 1 |
| 542 | _ | _ | |i 2024-07-03 |2 Crossref |u https://doi.org/10.15223/policy-029 |
| 542 | _ | _ | |i 2024-07-03 |2 Crossref |u https://doi.org/10.15223/policy-037 |
| 542 | _ | _ | |i 2024-07-03 |2 Crossref |u https://doi.org/10.15223/policy-045 |
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| 700 | 1 | _ | |a Liang, Kuan |b 1 |
| 700 | 1 | _ | |a Jaworek, Michel W. |b 2 |
| 700 | 1 | _ | |a Dong, Wanqian |b 3 |
| 700 | 1 | _ | |a Matsuo, Tatsuhito |b 4 |
| 700 | 1 | _ | |a Grélard, Axelle |b 5 |
| 700 | 1 | _ | |a Peters, Judith |0 0000-0001-5151-7710 |b 6 |
| 700 | 1 | _ | |a Winter, Roland |0 P:(DE-HGF)0 |b 7 |e Corresponding author |
| 700 | 1 | _ | |a Duan, Mojie |0 0000-0002-5496-832X |b 8 |e Corresponding author |
| 700 | 1 | _ | |a Kapoor, Shobhna |0 0000-0003-3684-4312 |b 9 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1021/acs.jpcb.4c02469 |b American Chemical Society (ACS) |d 2024-07-03 |n 28 |p 6838-6852 |3 journal-article |2 Crossref |t The Journal of Physical Chemistry B |v 128 |y 2024 |x 1520-6106 |
| 773 | _ | _ | |a 10.1021/acs.jpcb.4c02469 |g Vol. 128, no. 28, p. 6838 - 6852 |0 PERI:(DE-600)2006039-7 |n 28 |p 6838-6852 |t The journal of physical chemistry / B |v 128 |y 2024 |x 1520-6106 |
| 856 | 4 | _ | |u https://pubs.acs.org/doi/10.1021/acs.jpcb.4c02469 |
| 856 | 4 | _ | |u https://bib-pubdb1.desy.de/record/619000/files/Residual%20Membrane%20Fluidity%20in%20Mycobacterial%20Cell%20Envelope%20Layers%20under%20Extreme%20Conditions%20Underlines%20Membrane-Centric%20Adaptation.pdf |y Restricted |
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