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@ARTICLE{Gawel:618915,
author = {Gawel, Magdalena and Malecki, Piotr H. and Sliwiak, Joanna
and Stepniewska, Marlena and Imiolczyk, Barbara and
Czyrko-Horczak, Justyna and Jakubczyk, Dorota and Marczak,
Łukasz and Plonska-Brzezinska, Marta Eliza and Brzezinski,
Krzysztof},
title = {{A} closer look at molecular mechanisms underlying
inhibition of {S} -adenosyl- l -homocysteine hydrolase by
transition metal cations},
journal = {Chemical communications},
volume = {60},
number = {81},
issn = {1359-7345},
address = {Cambridge},
publisher = {Soc.},
reportid = {PUBDB-2024-07237},
pages = {11504-11507},
year = {2024},
note = {Waiting for fulltext},
abstract = {We report biochemical and structural studies on inhibiting
bacterial S-adenosyl-L-homocysteine hydrolase by transition
metal cations. Our results revealed diverse molecular
mechanisms of enzyme inactivation. Depending on the cation,
the mechanism is based on arresting the enzyme in its
closed, inactive conformation, disulfide bond formation
within the active site or oxidation of the intermediate form
of a cofactor.},
cin = {EMBL-User},
ddc = {540},
cid = {I:(DE-H253)EMBL-User-20120814},
pnm = {6G3 - PETRA III (DESY) (POF4-6G3)},
pid = {G:(DE-HGF)POF4-6G3},
experiment = {EXP:(DE-H253)P-P13-20150101},
typ = {PUB:(DE-HGF)16},
pubmed = {39230573},
UT = {WOS:001305719100001},
doi = {10.1039/D4CC03143A},
url = {https://bib-pubdb1.desy.de/record/618915},
}