TY  - JOUR
AU  - Gawel, Magdalena
AU  - Malecki, Piotr H.
AU  - Sliwiak, Joanna
AU  - Stepniewska, Marlena
AU  - Imiolczyk, Barbara
AU  - Czyrko-Horczak, Justyna
AU  - Jakubczyk, Dorota
AU  - Marczak, Łukasz
AU  - Plonska-Brzezinska, Marta Eliza
AU  - Brzezinski, Krzysztof
TI  - A closer look at molecular mechanisms underlying inhibition of S -adenosyl- l -homocysteine hydrolase by transition metal cations
JO  - Chemical communications
VL  - 60
IS  - 81
SN  - 1359-7345
CY  - Cambridge
PB  - Soc.
M1  - PUBDB-2024-07237
SP  - 11504-11507
PY  - 2024
N1  - Waiting for fulltext 
AB  - We report biochemical and structural studies on inhibiting bacterial S-adenosyl-L-homocysteine hydrolase by transition metal cations. Our results revealed diverse molecular mechanisms of enzyme inactivation. Depending on the cation, the mechanism is based on arresting the enzyme in its closed, inactive conformation, disulfide bond formation within the active site or oxidation of the intermediate form of a cofactor.
LB  - PUB:(DE-HGF)16
C6  - 39230573
UR  - <Go to ISI:>//WOS:001305719100001
DO  - DOI:10.1039/D4CC03143A
UR  - https://bib-pubdb1.desy.de/record/618915
ER  -