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@ARTICLE{DeSantis:617350,
author = {De Santis, Emiliano and Dawod, Ibrahim and André, Tomas
and Cardoch, Sebastian and Timneanu, Nicusor and Caleman,
Carl},
title = {{U}ltrafast {X}-ray laser-induced explosion: {H}ow the
depth influences the direction of the ion trajectory},
journal = {epl},
volume = {148},
number = {1},
issn = {0295-5075},
address = {Les Ulis},
publisher = {EDP Sciences},
reportid = {PUBDB-2024-06716},
pages = {17001},
year = {2024},
abstract = {Single particle imaging using X-ray lasers is a technique
aiming to capture atomicresolution structures of
biomolecules in their native state. Knowing the particle’s
orientationduring exposure is crucial for method
enhancement. It has been shown that the trajectories
ofsulfur atoms in a Coulomb exploding lysozyme are
reproducible, providing orientation information.This study
explores if sulfur atom depth influences explosion
trajectory. Employing a
hybridcollisional-radiative/molecular dynamics model, we
analyze the X-ray laser-induced dynamics ofa single sulfur
ion at varying depths in water. Our findings indicate that
the ion spread-depthrelationship depends on pulse
parameters. At a photon energy of 2 keV, high-charge states
areobtained, resulting in an increase of the spread with
depth. However, at 8 keV photon energy,where lower charge
states are obtained, the spread is essentially independent
with depth. Finally,lower ion mass results in less
reproducible trajectories, opening a promising route for
determiningprotein orientation through the introduction of
heavy atoms.},
cin = {FS-CFEL-1},
ddc = {530},
cid = {I:(DE-H253)FS-CFEL-1-20120731},
pnm = {633 - Life Sciences – Building Blocks of Life: Structure
and Function (POF4-633) / SPIDoc's - The Next Generation MS
SPIDoc’s (101120312) / MS SPIDOC - Mass Spectrometry for
Single Particle Imaging of Dipole Oriented protein Complexes
(801406)},
pid = {G:(DE-HGF)POF4-633 / G:(EU-Grant)101120312 /
G:(EU-Grant)801406},
experiment = {EXP:(DE-MLZ)NOSPEC-20140101},
typ = {PUB:(DE-HGF)16},
UT = {WOS:001332895500001},
doi = {10.1209/0295-5075/ad7883},
url = {https://bib-pubdb1.desy.de/record/617350},
}