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@ARTICLE{Kim:614236,
author = {Kim, Dojin and Bossi, Mariano L. and Belov, Vladimir N. and
Hell, Stefan W.},
title = {{S}upramolecular {C}omplex of {C}ucurbit[7]uril with
{D}iketopyrrolopyrole {D}ye: {F}luorescence {B}oost,
{B}iolabeling and {O}ptical {M}icroscopy},
journal = {Angewandte Chemie / International edition},
volume = {63},
number = {36},
issn = {1433-7851},
address = {Weinheim},
publisher = {Wiley-VCH},
reportid = {PUBDB-2024-05776},
pages = {e202410217},
year = {2024},
abstract = {New photostable and bright supramolecular complexes based
on cucurbit[7]uril (CB7) host and diketopyrrolopyrole (DPP)
guest dyes having two positively charged
4-(trimethylammonio)phenyl groups were prepared and
characterized. The dye core displays large Stokes shift (in
H2O, abs./emission max. 480/550 nm; ϵ~19 000, τfl>4
ns), strong binding with the host (~560 nM Kd) and a
linker affording fluorescence detection of bioconjugates
with antibody and nanobody. Combination of
protein-functionalized DPP dye with CB7 improves
photostability and affords up to 12-fold emission gain.
Two-color confocal and stimulated emission depletion (STED)
microscopy with 595 nm or 655 nm STED depletion lasers
shows that the presence of CB7 not only leads to improved
brightness and image quality, but also results in DPP
becoming cell-permeable.},
cin = {CSSB-CF-SPC},
ddc = {540},
cid = {I:(DE-H253)CSSB-CF-SPC-20210520},
pnm = {899 - ohne Topic (POF4-899)},
pid = {G:(DE-HGF)POF4-899},
experiment = {EXP:(DE-MLZ)NOSPEC-20140101},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:38881490},
UT = {WOS:001282939000001},
doi = {10.1002/anie.202410217},
url = {https://bib-pubdb1.desy.de/record/614236},
}