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@ARTICLE{Wolff:613902,
      author       = {Wolff, Georg and Limpens, Ronald W. A. L. and
                      Zevenhoven-Dobbe, Jessika C. and Laugks, Ulrike and Zheng,
                      Shawn and de Jong, Anja W. M. and Koning, Roman I. and
                      Agard, David A. and Gruenewald, Kay and Koster, Abraham J.
                      and Snijder, Eric J. and Bárcena, Montserrat},
      title        = {{A} molecular pore spans the double membrane of the
                      coronavirus replication organelle},
      journal      = {Science / Science now},
      volume       = {369},
      number       = {6509},
      issn         = {0036-8075},
      address      = {Washington, DC},
      publisher    = {Assoc.},
      reportid     = {PUBDB-2024-05681},
      pages        = {1395 - 1398},
      year         = {2020},
      note         = {ISSN 1095-9203 not unique: **3 hits**.},
      abstract     = {Coronavirus genome replication is associated with
                      virus-induced cytosolic double-membrane vesicles, which may
                      provide a tailored microenvironment for viral RNA synthesis
                      in the infected cell. However, it is unclear how newly
                      synthesized genomes and messenger RNAs can travel from these
                      sealed replication compartments to the cytosol to ensure
                      their translation and the assembly of progeny virions. In
                      this study, we used cellular cryo–electron microscopy to
                      visualize a molecular pore complex that spans both membranes
                      of the double-membrane vesicle and would allow export of RNA
                      to the cytosol. A hexameric assembly of a large viral
                      transmembrane protein was found to form the core of the
                      crown-shaped complex. This coronavirus-specific structure
                      likely plays a key role in coronavirus replication and thus
                      constitutes a potential drug target.},
      cin          = {CSSB-LIV-KG / CSSB-CF-CRYO},
      ddc          = {320},
      cid          = {I:(DE-H253)CSSB-LIV-KG-20220525 /
                      I:(DE-H253)CSSB-CF-CRYO-20210520},
      pnm          = {899 - ohne Topic (POF4-899) / DFG project 390874280 - EXC
                      2155: RESIST - Resolving Infection Susceptibility
                      (390874280) / SCORE - Swift COronavirus therapeutics
                      REsponse (101003627)},
      pid          = {G:(DE-HGF)POF4-899 / G:(GEPRIS)390874280 /
                      G:(EU-Grant)101003627},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32763915},
      UT           = {WOS:000569840300058},
      doi          = {10.1126/science.abd3629},
      url          = {https://bib-pubdb1.desy.de/record/613902},
}