000613902 001__ 613902
000613902 005__ 20250625124430.0
000613902 0247_ $$2doi$$a10.1126/science.abd3629
000613902 0247_ $$2ISSN$$a0036-8075
000613902 0247_ $$2ISSN$$a1095-9203
000613902 0247_ $$2ISSN$$a1947-8062
000613902 0247_ $$2datacite_doi$$a10.3204/PUBDB-2024-05681
000613902 0247_ $$2altmetric$$aaltmetric:87801844
000613902 0247_ $$2pmid$$apmid:32763915
000613902 0247_ $$2WOS$$aWOS:000569840300058
000613902 037__ $$aPUBDB-2024-05681
000613902 041__ $$aEnglish
000613902 082__ $$a320
000613902 1001_ $$00000-0002-1202-3344$$aWolff, Georg$$b0
000613902 245__ $$aA molecular pore spans the double membrane of the coronavirus replication organelle
000613902 260__ $$aWashington, DC$$bAssoc.$$c2020
000613902 3367_ $$2DRIVER$$aarticle
000613902 3367_ $$2DataCite$$aOutput Types/Journal article
000613902 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1725270075_1113237
000613902 3367_ $$2BibTeX$$aARTICLE
000613902 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000613902 3367_ $$00$$2EndNote$$aJournal Article
000613902 500__ $$aISSN 1095-9203 not unique: **3 hits**.
000613902 520__ $$aCoronavirus genome replication is associated with virus-induced cytosolic double-membrane vesicles, which may provide a tailored microenvironment for viral RNA synthesis in the infected cell. However, it is unclear how newly synthesized genomes and messenger RNAs can travel from these sealed replication compartments to the cytosol to ensure their translation and the assembly of progeny virions. In this study, we used cellular cryo–electron microscopy to visualize a molecular pore complex that spans both membranes of the double-membrane vesicle and would allow export of RNA to the cytosol. A hexameric assembly of a large viral transmembrane protein was found to form the core of the crown-shaped complex. This coronavirus-specific structure likely plays a key role in coronavirus replication and thus constitutes a potential drug target. 
000613902 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x0
000613902 536__ $$0G:(GEPRIS)390874280$$aDFG project 390874280 - EXC 2155: RESIST - Resolving Infection Susceptibility (390874280)$$c390874280$$x1
000613902 536__ $$0G:(EU-Grant)101003627$$aSCORE - Swift COronavirus therapeutics REsponse (101003627)$$c101003627$$fH2020-SC1-PHE-CORONAVIRUS-2020$$x2
000613902 588__ $$aDataset connected to DataCite
000613902 693__ $$0EXP:(DE-MLZ)NOSPEC-20140101$$5EXP:(DE-MLZ)NOSPEC-20140101$$eNo specific instrument$$x0
000613902 7001_ $$00000-0002-6243-6729$$aLimpens, Ronald W. A. L.$$b1
000613902 7001_ $$aZevenhoven-Dobbe, Jessika C.$$b2
000613902 7001_ $$0P:(DE-H253)PIP1092161$$aLaugks, Ulrike$$b3
000613902 7001_ $$00000-0001-9517-3075$$aZheng, Shawn$$b4
000613902 7001_ $$00000-0001-8110-8520$$ade Jong, Anja W. M.$$b5
000613902 7001_ $$00000-0001-6736-7147$$aKoning, Roman I.$$b6
000613902 7001_ $$00000-0003-3512-695X$$aAgard, David A.$$b7
000613902 7001_ $$0P:(DE-H253)PIP1023782$$aGruenewald, Kay$$b8
000613902 7001_ $$00000-0003-1717-2549$$aKoster, Abraham J.$$b9
000613902 7001_ $$00000-0003-3297-2309$$aSnijder, Eric J.$$b10
000613902 7001_ $$0P:(DE-HGF)0$$aBárcena, Montserrat$$b11$$eCorresponding author
000613902 773__ $$0PERI:(DE-600)2089761-3$$a10.1126/science.abd3629$$gVol. 369, no. 6509, p. 1395 - 1398$$n6509$$p1395 - 1398$$tScience / Science now$$v369$$x0036-8075$$y2020
000613902 8564_ $$uhttps://bib-pubdb1.desy.de/record/613902/files/science.abd3629.pdf$$yOpenAccess
000613902 8564_ $$uhttps://bib-pubdb1.desy.de/record/613902/files/science.abd3629.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000613902 909CO $$ooai:bib-pubdb1.desy.de:613902$$pdnbdelivery$$pec_fundedresources$$pVDB$$pdriver$$popen_access$$popenaire
000613902 9101_ $$0I:(DE-H253)_CSSB-20140311$$6P:(DE-H253)PIP1092161$$aCentre for Structural Systems Biology$$b3$$kCSSB
000613902 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1092161$$aExternal Institute$$b3$$kExtern
000613902 9101_ $$0I:(DE-H253)_CSSB-20140311$$6P:(DE-H253)PIP1023782$$aCentre for Structural Systems Biology$$b8$$kCSSB
000613902 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000613902 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)1200$$2StatID$$aDBCoverage$$bChemical Reactions$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)1210$$2StatID$$aDBCoverage$$bIndex Chemicus$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000613902 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)9950$$2StatID$$aIF >= 50$$bSCIENCE : 2022$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSCIENCE : 2022$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-24
000613902 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-24
000613902 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000613902 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-24
000613902 9201_ $$0I:(DE-H253)CSSB-LIV-KG-20220525$$kCSSB-LIV-KG$$lCSSB - Leibniz-Institut für Experimentelle Virologie (LIV) - Kay Grünewald$$x0
000613902 9201_ $$0I:(DE-H253)CSSB-CF-CRYO-20210520$$kCSSB-CF-CRYO$$lCSSB-CF-CRYO$$x1
000613902 980__ $$ajournal
000613902 980__ $$aVDB
000613902 980__ $$aUNRESTRICTED
000613902 980__ $$aI:(DE-H253)CSSB-LIV-KG-20220525
000613902 980__ $$aI:(DE-H253)CSSB-CF-CRYO-20210520
000613902 9801_ $$aFullTexts