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@ARTICLE{Listian:613730,
      author       = {Listian, Stevanus A. and Mazur, Anna-Carina and Kol,
                      Matthijs and Ufelmann, Edwin and Eising, Sebastian and
                      Fröhlich, Florian and Walter, Stefan and Holthuis, Joost C.
                      M. and Barisch, Caroline},
      title        = {{C}omplex {S}phingolipid {P}rofiling and {I}dentification
                      of an {I}nositol-{P}hosphorylceramide {S}ynthase in
                      {D}ictyostelium discoideum},
      journal      = {iScience},
      volume       = {27},
      number       = {9},
      issn         = {2589-0042},
      address      = {St. Louis},
      publisher    = {Elsevier},
      reportid     = {PUBDB-2024-05618},
      pages        = {110609},
      year         = {2024},
      abstract     = {Dictyostelium discoideum is a professional phagocyte
                      frequently used to study cellular processes underlying the
                      recognition, engulfment, and infection course of microbial
                      pathogens. Sphingolipids are abundant components of the
                      plasma membrane that bind cholesterol, control membrane
                      properties, participate in signal transmission, and serve as
                      adhesion molecules in recognition processes relevant to
                      immunity and infection. By combining lipidomics with a
                      bioinformatics-based cloning strategy, we show here that D.
                      discoideum produces phosphoinositol-containing sphingolipids
                      with predominantly phytoceramide backbones. Cell-free
                      expression of candidate inositol-phosphorylceramide (IPC)
                      synthases from D. discoideum enabled identification of an
                      enzyme that selectively catalyzes the transfer of
                      phosphoinositol from phosphatidylinositol onto ceramide. The
                      IPC synthase, DdIPCS1, shares multiple sequence motifs with
                      yeast IPC and human sphingomyelin synthases and localizes to
                      the Golgi apparatus as well as the contractile vacuole of D.
                      discoideum. These findings open up important opportunities
                      for exploring a role of sphingolipids in phagocytosis and
                      infection across major evolutionary boundaries.},
      cin          = {CSSB-FZB-CB},
      ddc          = {050},
      cid          = {I:(DE-H253)CSSB-FZB-CB-20230819},
      pnm          = {899 - ohne Topic (POF4-899) / SFB 1557 P01 - Umbau und
                      Nutzung der Lipid-Trafficking-Maschinerie der Wirtszelle
                      durch pathogene Mykobakterien (P01) (516902060) / SFB 1557
                      P07 - Untersuchung des Zusammenspiels zwischen der
                      Plastizität vakuolärer Kontaktstellen und der
                      Sphingolipid-Homöostase (P07) (516904847) / DFG project
                      G:(GEPRIS)531703706 - Entschlüsselung der molekularen
                      Mechanismen des Austritts von Orientia tsutsugamushi aus der
                      Wirtszelle (531703706)},
      pid          = {G:(DE-HGF)POF4-899 / G:(GEPRIS)516902060 /
                      G:(GEPRIS)516904847 / G:(GEPRIS)531703706},
      experiment   = {EXP:(DE-H253)ALFM-20250101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39286488},
      UT           = {WOS:001307900600001},
      doi          = {10.1016/j.isci.2024.110609},
      url          = {https://bib-pubdb1.desy.de/record/613730},
}