000607380 001__ 607380 000607380 005__ 20240602054223.0 000607380 0247_ $$2arXiv$$aarXiv:1912.10796 000607380 0247_ $$2datacite_doi$$a10.3204/PUBDB-2024-01862 000607380 037__ $$aPUBDB-2024-01862 000607380 041__ $$aEnglish 000607380 082__ $$a530 000607380 088__ $$2arXiv$$aarXiv:1912.10796 000607380 1001_ $$aSobolev, Egor$$b0 000607380 245__ $$aMegahertz single-particle imaging at the European XFEL 000607380 260__ $$c2020 000607380 3367_ $$0PUB:(DE-HGF)25$$2PUB:(DE-HGF)$$aPreprint$$bpreprint$$mpreprint$$s1716892465_3206570 000607380 3367_ $$2ORCID$$aWORKING_PAPER 000607380 3367_ $$028$$2EndNote$$aElectronic Article 000607380 3367_ $$2DRIVER$$apreprint 000607380 3367_ $$2BibTeX$$aARTICLE 000607380 3367_ $$2DataCite$$aOutput Types/Working Paper 000607380 520__ $$aThe emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL will soon provide 27,000 pulses per second, more than two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. 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