TY  - JOUR
AU  - Johny, Melby
AU  - Schouder, Constant A.
AU  - Al-Refaie, Ahmed
AU  - He, Lanhai
AU  - Wiese, Joss
AU  - Stapelfeldt, Henrik
AU  - Trippel, Sebastian
AU  - Küpper, Jochen
TI  - Water is a radiation protection agent for ionised pyrrole
JO  - Physical chemistry, chemical physics
VL  - 26
IS  - 17
SN  - 1463-9076
CY  - Cambridge
PB  - RSC Publ.
M1  - PUBDB-2024-01291
M1  - arXiv:2010.00453
SP  - 13118-13130
PY  - 2024
AB  - Radiation-induced damage of biological matter is an ubiquitous problem in nature. The influence   of the hydration environment is widely discussed, but its exact role remains elusive. Utilising   well defined solvated-molecule aggregates, we experimentally observed a hydrogen-bonded water   molecule acting as a radiation protection agent for ionised pyrrole, a prototypical aromatic   biomolecule. Pure samples of pyrrole and pyrrole(H<sub>2</sub>O) were outer-valence ionised and the subsequent   damage and relaxation processes were studied. Bare pyrrole ions fragmented through the breaking   of C−C or N−C covalent bonds. However, for pyrrole(H<sub>2</sub>O)<sup>+</sup>, we observed a strong protection of the   pyrrole ring through the dissociative release of neutral water or by transferring an electron or   proton across the hydrogen bond. Overall, a single water molecule strongly reduces the   fragmentation probability and thus the persistent radiation damage of singly-ionised pyrrole.
LB  - PUB:(DE-HGF)16
C6  - 38629233
UR  - <Go to ISI:>//WOS:001204249800001
DO  - DOI:10.1039/D3CP03471B
UR  - https://bib-pubdb1.desy.de/record/605016
ER  -